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Science 1 February 1985:
Vol. 227. no. 4686, pp. 545 - 548
DOI: 10.1126/science.2981439
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Articles

Science, Vol 227, Issue 4686, 545-548
Copyright © 1985 by American Association for the Advancement of Science

articles

Hypothalamic reward mechanism: two first-stage fiber populations with a cholinergic component

A Gratton and RA Wise

Refractory periods were estimated for fibers of the hypothalamic substrate of brain stimulation reward. Two nonoverlapping populations were evident: a homogeneous fast population and a more heterogeneous slow population. Cholinergic blockade eliminated the contribution of the fast but not the slow fibers, while dopaminergic blockade reduced responding without significantly influencing either directly activated fiber population. These data indicate that the hypothalamic reward substrate is more complex than has been widely appreciated; it contains two or more parallel subsystems, and one of these subsystems has a cholinergic link.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Rewarding Effects of the Cholinergic Agents Carbachol and Neostigmine in the Posterior Ventral Tegmental Area.
S. Ikemoto and R. A. Wise (2002)
J. Neurosci. 22, 9895-9904
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