Related Content
Search Google Scholar for:
|
|
Science 1 February 1985:
Vol. 227. no. 4686, pp. 538 - 540
DOI: 10.1126/science.2981438
|
|
Articles
Science, Vol 227, Issue 4686, 538-540
Copyright © 1985 by American Association for the Advancement of Science
Characterization of long terminal repeat sequences of HTLV-III
B Starcich,
L Ratner,
SF Josephs,
T Okamoto,
RC Gallo,
and
F Wong-Staal
The nucleotide sequence of the long terminal repeat sequence (LTR) of the human T-cell leukemia (lymphotropic) virus type III (HTLV-III) was determined. This virus is associated etiologically with the acquired immune deficiency syndrome. The LTR was found to be 634 base pairs in length with U3, R, and U5 regions of 453, 98, and 83 bp, respectively. The proviral DNA is flanked by a 7-base-pair direct repeat. The promoter and polyadenylation signals are situated 27 and 24 base pairs upstream from the respective transcriptional initiation and polyadenylation sites. The primer binding site is complementary to transfer RNA-lysine. The LTR of HTLV-III, like that of HTLV-I, showed a limited homology to enhancer-like sequences within two genes expressed specifically in T lymphocytes, T-cell growth factor, and gamma-interferon. Structural comparisons revealed that the LTR of HTLV-III is distantly related to those of HTLV-I, HTLV-II, and bovine leukemia virus.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- RelA-Associated Inhibitor Blocks Transcription of Human Immunodeficiency Virus Type 1 by Inhibiting NF-{kappa}B and Sp1 Actions.
- N. Takada, T. Sanda, H. Okamoto, J.-P. Yang, K. Asamitsu, L. Sarol, G. Kimura, H. Uranishi, T. Tetsuka, and T. Okamoto (2002)
J. Virol.
76, 8019-8030
| Abstract »
| Full Text »
| PDF »
- Presteady-state Analysis of Avian Sarcoma Virus Integrase. II. REVERSE-POLARITY SUBSTRATES IDENTIFY PREFERENTIAL PROCESSING OF THE U3-U5 PAIR.
- K. K. Bao, A. M. Skalka, and I. Wong (2002)
J. Biol. Chem.
277, 12099-12108
| Abstract »
| Full Text »
| PDF »
- Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Target Distinct Phases of Early Reverse Transcription.
- C. W. Hooker, W. B. Lott, and D. Harrich (2001)
J. Virol.
75, 3095-3104
| Abstract »
| Full Text »
| PDF »
- Modulation of Human Immunodeficiency Virus Type 1-Induced Syncytium Formation by the Conformational State of LFA-1 Determined by a New Luciferase-Based Syncytium Quantitative Assay.
- B. Barbeau, J.-F. Fortin, N. Genois, and M. J. Tremblay (1998)
J. Virol.
72, 7125-7136
| Abstract »
| Full Text »
| PDF »
- HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene.
- D. Ballard, E Bohnlein, J. Lowenthal, Y Wano, B. Franza, and W. Greene (1988)
Science
241, 1652-1655
| Abstract »
| PDF »
- The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites.
- B. Franza Jr, F. Rauscher 3rd, S. Josephs, and T Curran (1988)
Science
239, 1150-1153
| Abstract »
| PDF »
- Site-directed mutagenesis of two trans-regulatory genes (tat-III,trs) of HIV-1.
- M. Sadaie, T Benter, and F Wong-Staal (1988)
Science
239, 910-913
| Abstract »
| PDF »
- Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-I.
- M Siekevitz, S. Josephs, M Dukovich, N Peffer, F Wong-Staal, and W. Greene (1987)
Science
238, 1575-1578
| Abstract »
| PDF »
- Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1.
- K. Jones, J. Kadonaga, P. Luciw, and R Tjian (1986)
Science
232, 755-759
| Abstract »
| PDF »
- cis- and trans-acting transcriptional regulation of visna virus.
- J. Hess, J. Clements, and O Narayan (1985)
Science
229, 482-485
| Abstract »
| PDF »
- The Acquired Immunodeficiency Syndrome: An Update.
- A. S. FAUCI, H. MASUR, E. P. GELMANN, P. D. MARKHAM, B. H. HAHN, and H. C. LANE (1985)
Ann Intern Med
102, 800-813
| Abstract »
| PDF »
|
|
