Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 1 February 1985:
Vol. 227. no. 4686, pp. 535 - 538
DOI: 10.1126/science.3966161
Prev | Table of Contents | Next

Articles

Science, Vol 227, Issue 4686, 535-538
Copyright © 1985 by American Association for the Advancement of Science

articles

Vaccination against Schistosoma mansoni with purified surface antigens

MA Smith and JA Clegg

Two surface antigens were isolated from young or adult schistosomes by affinity chromatography with monoclonal antibodies. Vaccination with an antigen having a molecular weight of 155,000 gave partial protection against challenge in some batches of mice and in a group of cynomolgus monkeys. Vaccination with an antigen having a molecular weight of 53,000 gave similar levels of protection in mice. The results demonstrate that protection can be obtained with single antigens, but the precise requirements for reproducible vaccination are as yet unknown.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of paramyosin as schistosome antigen recognized by intradermally vaccinated mice.
D. Lanar, E. Pearce, S. James, and A Sher (1986)
Science 234, 593-596
   Abstract »    PDF »
Rat resistance to schistosomiasis: platelet-mediated cytotoxicity induced by C-reactive protein.
D Bout, M Joseph, M Pontet, H Vorng, D Deslee, and A Capron (1986)
Science 231, 153-156
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)