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Science 1 February 1985:
Vol. 227. no. 4686, pp. 533 - 535
DOI: 10.1126/science.3917578
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Articles

Science, Vol 227, Issue 4686, 533-535
Copyright © 1985 by American Association for the Advancement of Science

articles

Insulin mediators from rat skeletal muscle have differential effects on insulin-sensitive pathways of intact adipocytes

L Jarett, EH Wong, SL Macaulay, and JA Smith

The effects of partially purified insulin-generated mediators from rat skeletal muscle were compared to those of insulin on intact adipocytes. Insulin and insulin mediator stimulated both pyruvate dehydrogenase and glycogen synthase activity of intact adipocytes. In contrast, insulin stimulated glucose oxidation and 3-O-methylglucose transport, whereas insulin-generated mediators had no effect. Insulin-generated mediators cannot account for all the pleiotropic effects of insulin, especially membrane-controlled processes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Phosphatidylinositol-glycan anchors of membrane proteins: potential precursors of insulin mediators.
G Romero, L Luttrell, A Rogol, K Zeller, E Hewlett, and J Larner (1988)
Science 240, 509-511
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