Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 1 February 1985:
Vol. 227. no. 4686, pp. 531 - 533
DOI: 10.1126/science.2578228
Prev | Table of Contents | Next

Articles

Science, Vol 227, Issue 4686, 531-533
Copyright © 1985 by American Association for the Advancement of Science

articles

The role of hemoglobin denaturation and band 3 clustering in red blood cell aging

PS Low, SM Waugh, K Zinke, and D Drenckhahn

As hemoglobin begins to denature, it forms hemichromes that cross-link the major erythrocyte membrane-spanning protein, band 3, into clusters. These clusters provide the recognition site for antibodies directed against senescent cells. These antibodies bind to the aged red cell and trigger its removal from circulation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Loss of Specific Chaperones Involved in Membrane Glycoprotein Biosynthesis during the Maturation of Human Erythroid Progenitor Cells.
S. T. Patterson, J. Li, J.-A. Kang, A. Wickrema, D. B. Williams, and R. A. F. Reithmeier (2009)
J. Biol. Chem. 284, 14547-14557
   Abstract »    Full Text »    PDF »
Red cell membrane: past, present, and future.
N. Mohandas and P. G. Gallagher (2008)
Blood 112, 3939-3948
   Abstract »    Full Text »    PDF »
Enhanced suicidal death of erythrocytes from gene-targeted mice lacking the Cl-/HCO3- exchanger AE1.
A. Akel, C. A. Wagner, J. Kovacikova, Ravi. S. Kasinathan, V. Kiedaisch, S. Koka, S. L. Alper, I. Bernhardt, T. Wieder, S. M. Huber, et al. (2007)
Am J Physiol Cell Physiol 292, C1759-C1767
   Abstract »    Full Text »    PDF »
Band 3 modifications in Plasmodium falciparum-infected AA and CC erythrocytes assayed by autocorrelation analysis using quantum dots.
F. Tokumasu, R. M. Fairhurst, G. R. Ostera, N. J. Brittain, J. Hwang, T. E. Wellems, and J. A. Dvorak (2005)
J. Cell Sci. 118, 1091-1098
   Abstract »    Full Text »    PDF »
Enhanced phagocytosis of ring-parasitized mutant erythrocytes: a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait.
K. Ayi, F. Turrini, A. Piga, and P. Arese (2004)
Blood 104, 3364-3371
   Abstract »    Full Text »    PDF »
The Substrate Anion Selectivity Filter in the Human Erythrocyte Cl-/HCO3 Exchange Protein, AE1.
Q. Zhu and J. R. Casey (2004)
J. Biol. Chem. 279, 23565-23573
   Abstract »    Full Text »    PDF »
Acridine orange induces translocation of phosphatidylserine to red blood cell surface.
A. Koshkaryev, S. Yedgar, H. Relevy, E. Fibach, and G. Barshtein (2003)
Am J Physiol Cell Physiol 285, C720-C722
   Abstract »    Full Text »    PDF »
Splenectomy prolongs in vivo survival of erythrocytes differently in spectrin/ankyrin- and band 3-deficient hereditary spherocytosis.
R. Reliene, M. Mariani, A. Zanella, W. H. Reinhart, M. L. Ribeiro, E. M. del Giudice, S. Perrotta, A. Iolascon, S. Eber, and H. U. Lutz (2002)
Blood 100, 2208-2215
   Abstract »    Full Text »    PDF »
Glutathione protects chemokine-scavenging and antioxidative defense functions in human RBCs.
U. J. Dumaswala, L. Zhuo, S. Mahajan, P. N. M. Nair, H. G. Shertzer, P. Dibello, and D. W. Jacobsen (2001)
Am J Physiol Cell Physiol 280, C867-C873
   Abstract »    Full Text »    PDF »
Crystallographic structure and functional interpretation of the cytoplasmic domain of erythrocyte membrane band 3.
D. Zhang, A. Kiyatkin, J. T. Bolin, and P. S. Low (2000)
Blood 96, 2925-2933
   Abstract »    Full Text »    PDF »
Evaluation of Biochemical Changes During In Vivo Erythrocyte Senescence in the Dog.
M. P. Rettig, P. S. Low, J. A. Gimm, N. Mohandas, J. Wang, and J. A. Christian (1999)
Blood 93, 376-384
   Abstract »    Full Text »    PDF »
Effect of Band 3 Subunit Equilibrium on the Kinetics and Affinity of Ankyrin Binding to Erythrocyte Membrane Vesicles.
H. M. Van Dort, R. Moriyama, and P. S. Low (1998)
J. Biol. Chem. 273, 14819-14826
   Abstract »    Full Text »    PDF »
Phosphatidylserine exposure and red cell viability in red cell aging and in hemolytic anemia.
F. E. Boas, L. Forman, and E. Beutler (1998)
PNAS 95, 3077-3081
   Abstract »    Full Text »    PDF »
Role of cadherins and plakoglobin in interendothelial adhesion under resting conditions and shear stress.
H.-J. Schnittler, B. Puschel, and D. Drenckhahn (1997)
Am J Physiol Heart Circ Physiol 273, H2396-H2405
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)