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Science 1 February 1985:
Vol. 227. no. 4686, pp. 484 - 492
DOI: 10.1126/science.2578227

Articles

Science, Vol 227, Issue 4686, 484-492
Copyright © 1985 by American Association for the Advancement of Science


articles

Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2)

R Sanchez-Pescador, MD Power, PJ Barr, KS Steimer, MM Stempien, SL Brown-Shimer, WW Gee, A Renard, A Randolph, JA Levy, and al. et

The nucleotide sequence of molecular clones of DNA from a retrovirus, ARV-2, associated with the acquired immune deficiency syndrome (AIDS) was determined. Proviral DNA of ARV-2 (9737 base pairs) has long terminal repeat structures (636 base pairs) and long open reading frames encoding gag (506 codons), pol (1003 codons), and env (863 codons) genes. Two additional open reading frames were identified. Significant amino acid homology with several other retroviruses was noted in the predicted product of gag and pol, but ARV-2 was as closely related to murine and avian retroviruses as it was to human T-cell leukemia viruses (HTLV-I and HTLV-II). By means of an SV-40 vector in transfected simian cells, the cloned gag and env genes of ARV-2 were shown to express viral proteins.


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J. Allan, J. Coligan, T. Lee, M. McLane, P. Kanki, J. Groopman, and M Essex (1985)
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Prospects of Therapy for Infections with Human T-Lymphotropic Virus Type III.
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Transcription of novel open reading frames of AIDS retrovirus during infection of lymphocytes.
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Characterization of gp41 as the transmembrane protein coded by the HTLV-III/LAV envelope gene.
F. Veronese, A. DeVico, T. Copeland, S Oroszlan, R. Gallo, and M. Sarngadharan (1985)
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Genomic diversity of human T-lymphotropic virus type III (HTLV-III).
F Wong-Staal, G. Shaw, B. Hahn, S. Salahuddin, M Popovic, P Markham, R Redfield, and R. Gallo (1985)
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Infection With HTLV-III/LAV and Transfusion-Associated Acquired Immunodeficiency Syndrome: Serologic Evidence of an Association.
H. W. Jaffe, M. G. Sarngadharan, A. L. DeVico, L. Bruch, J. P. Getchell, V. S. Kalyanaraman, H. W. Haverkos, R. L. Stoneburner, R. C. Gallo, and J. W. Curran (1985)
JAMA 254, 770-773
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S Harada, Y Koyanagi, and N Yamamoto (1985)
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cis- and trans-acting transcriptional regulation of visna virus.
J. Hess, J. Clements, and O Narayan (1985)
Science 229, 482-485
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Trans-activator gene of human T-lymphotropic virus type III (HTLV-III).
S. Arya, C Guo, S. Josephs, and F Wong-Staal (1985)
Science 229, 69-73
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Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.
J Sodroski, R Patarca, C Rosen, F Wong-Staal, and W Haseltine (1985)
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M Seiki, A Hikikoshi, T Taniguchi, and M Yoshida (1985)
Science 228, 1532-1534
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Virus envelope protein of HTLV-III represents major target antigen for antibodies in AIDS patients.
F Barin, M. McLane, J. Allan, T. Lee, J. Groopman, and M Essex (1985)
Science 228, 1094-1096
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A virus by any other name . ..
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Science 227, 1449-1451
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   Abstract »    Full Text »    PDF »
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A. Manninen, G. Herma Renkema, and K. Saksela (2000)
J. Biol. Chem. 275, 16513-16517
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H. C. Ha, K. Juluri, Y. Zhou, S. Leung, M. Hermankova, and S. H. Snyder (2001)
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HIV envelope gp120 activates human arterial smooth muscle cells.
A. D. Schecter, A. B. Berman, L. Yi, A. Mosoian, C. M. McManus, J. W. Berman, M. E. Klotman, and M. B. Taubman (2001)
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