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Science 25 January 1985:
Vol. 227. no. 4685, pp. 438 - 440
DOI: 10.1126/science.4038426
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Articles

Science, Vol 227, Issue 4685, 438-440
Copyright © 1985 by American Association for the Advancement of Science

articles

Ascorbic acid and the behavioral response to haloperidol: implications for the action of antipsychotic drugs

GV Rebec, JM Centore, LK White, and KD Alloway

Haloperidol, a widely used antipsychotic drug, was tested for its ability to block the behavioral response to amphetamine and to elicit catalepsy in rats treated with saline or ascorbic acid (1000 milligrams per kilogram of body weight). By itself, ascorbic acid failed to exert significant behavioral effects, but it enhanced the antiamphetamine and cataleptogenic effects of haloperidol (0.1 or 0.5 milligrams per kilogram). These results, combined with a growing body of biochemical evidence, suggest that ascorbic acid plays an important role in modulating the behavioral effects of haloperidol and related antipsychotic drugs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Behavioral Activation in Rats Requires Endogenous Ascorbate Release in Striatum.
G. V. Rebec and Z. Wang (2001)
J. Neurosci. 21, 668-675
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Science. ISSN 0036-8075 (print), 1095-9203 (online)