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Science 25 January 1985:
Vol. 227. no. 4685, pp. 433 - 435
DOI: 10.1126/science.2981435
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Articles
Science, Vol 227, Issue 4685, 433-435
Copyright © 1985 by American Association for the Advancement of Science
Vaccinia virus recombinants: expression of VSV genes and protective immunization of mice and cattle
M Mackett,
T Yilma,
JK Rose,
and
B Moss
Vesicular stomatitis virus (VSV) causes a contagious disease of horses, cattle, and pigs. When DNA copies of messenger RNA's for the G or N proteins of VSV were linked to a vaccinia virus promoter and inserted into the vaccinia genome, the recombinants retained infectivity and synthesized VSV polypeptides. After intradermal vaccination with live recombinant virus expressing the G protein, mice produced VSV-neutralizing antibodies and were protected against lethal encephalitis upon intravenous challenge with VSV. In cattle, the degree of protection against intradermalingually injected VSV was correlated with the level of neutralizing antibody produced following vaccination.
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