Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 25 January 1985:
Vol. 227. no. 4685, pp. 424 - 426
DOI: 10.1126/science.3155575
Prev | Table of Contents | Next

Articles

Science, Vol 227, Issue 4685, 424-426
Copyright © 1985 by American Association for the Advancement of Science

articles

Induction of the intermediate pituitary by stress: synthesis and release of a nonopioid form of beta-endorphin

H Akil, H Shiomi, and J Matthews

beta-Endorphin in the intermediate lobe of the pituitary gland is posttranslationally modified to produce opioid inactive peptides. Whether these are metabolites or biologically relevant products has not been known. It was found that repeated stress induces increased biosynthesis and release of beta-endorphin-like substances from the intermediate lobe of rats and that opioid-inactive N-acetylated beta-endorphin-(1-31) is selectively made and liberated. The possible role of this nonopioid product and the selective release of peptide forms are discussed.




To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)