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Science 25 January 1985:
Vol. 227. no. 4685, pp. 413 - 415
DOI: 10.1126/science.2578225
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Articles
Science, Vol 227, Issue 4685, 413-415
Copyright © 1985 by American Association for the Advancement of Science
Myosin: a link between streptococci and heart
K Krisher
and
MW Cunningham
Murine monoclonal antibodies to Streptococcus pyogenes reacted with skeletal muscle myosin. High molecular weight proteins in extracts of human heart tissue that reacted with an antibody to S. pyogenes also reacted with a monoclonal antibody to ventricular myosin. Adsorption of the antibody to streptococci with S. pyogenes simultaneously removed reactivity of the antibody for either S. pyogenes or myosin. These results indicate that myosin shares immunodeterminants with a component of S. pyogenes.
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