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Science 18 January 1985:
Vol. 227. no. 4684, pp. 320 - 322
DOI: 10.1126/science.2981432
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Articles

Science, Vol 227, Issue 4684, 320-322
Copyright © 1985 by American Association for the Advancement of Science

articles

Trans activation of the bovine leukemia virus long terminal repeat in BLV-infected cells

CA Rosen, JG Sodroski, R Kettman, A Burny, and WA Haseltine

The transcription initiation signals for retroviruses lie within the long terminal repeat (LTR) sequences that flank the integrated provirus. This study shows that factors present in cells infected with bovine leukemia virus (BLV) mediate transcriptional trans activation of the BLV LTR. This phenomenon is similar to that reported for the human T-cell leukemia virus LTR and establishes both structural and functional criteria for inclusion of BLV and human T-cell leukemia viruses in the same family of transforming retroviruses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Duplicated Sequence Motif in the Long Terminal Repeat of Maedi-Visna Virus Extends Cell Tropism and Is Associated with Neurovirulence.
T. Oskarsson, H. S. Hreggvidsdottir, G. Agnarsdottir, S. Matthiasdottir, M. H. Ogmundsdottir, S. R. Jonsson, G. Georgsson, S. Ingvarsson, O. S. Andresson, and V. Andresdottir (2007)
J. Virol. 81, 4052-4057
   Abstract »    Full Text »    PDF »
In Vivo Rescue of a Silent tax-Deficient Bovine Leukemia Virus from a Tumor-Derived Ovine B-Cell Line by Recombination with a Retrovirally Transduced Wild-Type tax Gene.
A. Van Den Broeke, C. Bagnis, M. Ciesiolka, Y. Cleuter, H. Gelderblom, P. Kerkhofs, P. Griebel, P. Mannoni, and A. Burny (1999)
J. Virol. 73, 1054-1065
   Abstract »    Full Text »
An Interferon Regulatory Factor Binding Site in the U5 Region of the Bovine Leukemia Virus Long Terminal Repeat Stimulates Tax-Independent Gene Expression.
V. Kiermer, C. Van Lint, D. Briclet, C. Vanhulle, R. Kettmann, E. Verdin, A. Burny, and L. Droogmans (1998)
J. Virol. 72, 5526-5534
   Abstract »    Full Text »    PDF »
In vivo competition between a metallothionein regulatory element and the SV40 enhancer.
H Scholer, A Haslinger, A Heguy, H Holtgreve, and M Karin (1986)
Science 232, 76-80
   Abstract »    PDF »
Two elements in the bovine leukemia virus long terminal repeat that regulate gene expression.
D Derse and J. Casey (1986)
Science 231, 1437-1440
   Abstract »    PDF »
A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients.
J. Allan, J. Coligan, T. Lee, M. McLane, P. Kanki, J. Groopman, and M Essex (1985)
Science 230, 810-813
   Abstract »    PDF »
cis- and trans-acting transcriptional regulation of visna virus.
J. Hess, J. Clements, and O Narayan (1985)
Science 229, 482-485
   Abstract »    PDF »
Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.
J Sodroski, R Patarca, C Rosen, F Wong-Staal, and W Haseltine (1985)
Science 229, 74-77
   Abstract »    PDF »
HTLV x-gene product: requirement for the env methionine initiation codon.
W Wachsman, D. Golde, P. Temple, E. Orr, S. Clark, and I. Chen (1985)
Science 228, 1534-1537
   Abstract »    PDF »
A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus.
J Sodroski, C Rosen, W. Goh, and W Haseltine (1985)
Science 228, 1430-1434
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)