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Science 18 January 1985:
Vol. 227. no. 4684, pp. 311 - 314
DOI: 10.1126/science.3871253
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Articles

Science, Vol 227, Issue 4684, 311-314
Copyright © 1985 by American Association for the Advancement of Science

articles

Partial primary structure of the alpha and beta chains of human tumor T-cell receptors

N Jones, J Leiden, D Dialynas, J Fraser, M Clabby, T Kishimoto, JL Strominger, D Andrews, W Lane, and J Woody

The T-cell receptor for antigen (Ti) was purified from the human tumor cell line HPB-ALL. Amino-terminal sequence analysis of an acid-cleaved peptide of the Ti alpha chain showed that it is highly homologous to a putative murine alpha chain recently described. Amino-terminal sequence analysis of the Ti beta chain revealed that it shares 50 percent homology with the Ti beta chain amino acid sequences from two other human T-cell tumors. Nucleotide sequence analysis of a complementary DNA clone encoding the Ti beta chain from the HPB-MLT cell line showed that this chain represents a second human constant region gene segment and suggested that it arises from direct joining of the variable and joining gene segments without any intervening D region sequences.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structure and diversity of the human T-cell receptor beta-chain variable region genes.
J. Tillinghast, M. Behlke, and D. Loh (1986)
Science 233, 879-883
   Abstract »    PDF »
Human T-cell Receptor Genes: Organization, Diversity, and Polymorphism.
P. Concannon, E. Lai, M. Klein, S. Siu, E. Strauss, L. Pickering, P. Kung, R. Gatti, and L. Hood (1986)
Cold Spring Harb Symp Quant Biol 51, 785-795
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)