Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 18 January 1985:
Vol. 227. no. 4684, pp. 266 - 270
DOI: 10.1126/science.3917575
Prev | Table of Contents | Next

Articles

Science, Vol 227, Issue 4684, 266-270
Copyright © 1985 by American Association for the Advancement of Science

articles

Immunoglobulin heavy-chain enhancer requires one or more tissue-specific factors

M Mercola, J Goverman, C Mirell, and K Calame

Enhancer sequences are regulatory regions that greatly increase transcription of certain eukaryotic genes. An immunoglobulin heavy-chain variable gene segment is moved from a region lacking enhancer activity to a position adjacent to the known heavy-chain enhancer early in B-cell maturation. In lymphoid cells, the heavy-chain and SV40 enhancers bind a common factor essential for enhancer function. In contrast, fibroblast cells contain a functionally distinct factor that is used by the SV40 but not by the heavy-chain enhancer. The existence of different factors in these cells may explain the previously described lymphoid cell specificity of the heavy-chain enhancer.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Requirement for Enhancer Specificity in Immunoglobulin Heavy Chain Locus Regulation.
I. I. Kuzin, L. Bagaeva, F. M. Young, and A. Bottaro (2008)
J. Immunol. 180, 7443-7450
   Abstract »    Full Text »    PDF »
The COOH-terminal Transactivation Domain Plays a Key Role in Regulating the in Vitro and in Vivo Function of Pax3 Homeodomain.
Y. Cao and C. Wang (2000)
J. Biol. Chem. 275, 9854-9862
   Abstract »    Full Text »    PDF »
Tumor-Specific PAX3-FKHR Transcription Factor, but Not PAX3, Activates the Platelet-Derived Growth Factor Alpha Receptor.
J. A. Epstein, B. Song, M. Lakkis, and C. Wang (1998)
Mol. Cell. Biol. 18, 4118-4130
   Abstract »    Full Text »
A dominant negative form of transcription activator mTFE3 created by differential splicing.
C Roman, L Cohn, and K Calame (1991)
Science 254, 94-97
   Abstract »    PDF »
Identification of a potent adipocyte-specific enhancer: involvement of an NF-1-like factor..
R A Graves, P Tontonoz, S R Ross, and B M Spiegelman (1991)
Genes & Dev. 5, 428-437
   Abstract »    PDF »
Evidence for a complex regulatory array in the first intron of the human adenosine deaminase gene..
B Aronow, D Lattier, R Silbiger, M Dusing, J Hutton, G Jones, J Stock, J McNeish, S Potter, and D Witte (1989)
Genes & Dev. 3, 1384-1400
   Abstract »    PDF »
A developmental-specific factor binds to suppressor sites flanking the immunoglobulin heavy-chain enhancer..
R H Scheuermann and U Chen (1989)
Genes & Dev. 3, 1255-1266
   Abstract »    PDF »
I kappa B: a specific inhibitor of the NF-kappa B transcription factor.
P. Baeuerle and D Baltimore (1988)
Science 242, 540-546
   Abstract »    PDF »
A transcriptional enhancer 3' of C beta 2 in the T cell receptor beta locus.
S McDougall, C. Peterson, and K Calame (1988)
Science 241, 205-208
   Abstract »    PDF »
Limited transcription of rat elastase I transgene repeats in transgenic mice..
B P Davis and R J MacDonald (1988)
Genes & Dev. 2, 13-22
   Abstract »    PDF »
In vitro binding of several cell-specific and ubiquitous nuclear proteins to the GT-I motif of the SV40 enhancer..
J H Xiao, I Davidson, M Macchi, R Rosales, M Vigneron, A Staub, and P Chambon (1987)
Genes & Dev. 1, 794-807
   Abstract »    PDF »
Lens-specific enhancer in the third intron regulates expression of the chicken delta 1-crystallin gene..
S Hayashi, K Goto, T S Okada, and H Kondoh (1987)
Genes & Dev. 1, 818-828
   Abstract »    PDF »
Identification by cell fusion of gene sequences that interact with positive trans-acting factors.
T Lufkin and C Bancroft (1987)
Science 237, 283-286
   Abstract »    PDF »
Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility.
M Lenardo, J. Pierce, and D Baltimore (1987)
Science 236, 1573-1577
   Abstract »    PDF »
Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses..
P F Johnson, W H Landschulz, B J Graves, and S L McKnight (1987)
Genes & Dev. 1, 133-146
   Abstract »    PDF »
Two different cis-active elements transfer the transcriptional effects of both EGF and phorbol esters.
H. Elsholtz, H. Mangalam, E Potter, V. Albert, S Supowit, R. Evans, and M. Rosenfeld (1986)
Science 234, 1552-1557
   Abstract »    PDF »
In vivo competition between a metallothionein regulatory element and the SV40 enhancer.
H Scholer, A Haslinger, A Heguy, H Holtgreve, and M Karin (1986)
Science 232, 76-80
   Abstract »    PDF »
Tissue-specific expression in transgenic mice of a fused gene containing RSV terminal sequences.
P. Overbeek, S. Lai, K. Van Quill, and H Westphal (1986)
Science 231, 1574-1577
   Abstract »    PDF »
Repression of the immunoglobulin heavy chain enhancer by the adenovirus-2 E1A products.
R Hen, E Borrelli, and P Chambon (1985)
Science 230, 1391-1394
   Abstract »    PDF »
Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5' flanking elements.
T Edlund, M. Walker, P. Barr, and W. Rutter (1985)
Science 230, 912-916
   Abstract »    PDF »
Plasticity of the differentiated state.
H. Blau, G. Pavlath, E. Hardeman, C. Chiu, L Silberstein, S. Webster, S. Miller, and C Webster (1985)
Science 230, 758-766
   Abstract »    PDF »
Contribution of promoter to tissue-specific expression of the mouse immunoglobulin kappa gene.
T. Gopal, T Shimada, A. Baur, and A. Nienhuis (1985)
Science 229, 1102-1104
   Abstract »    PDF »
Promoter Sequences of Murine {alpha}A Crystallin, Murine {alpha}2(I) Collagen or of Avian Sarcoma Virus Genes Linked to the Bacterial Chloramphenicol Acetyl Transferase Gene Direct Tissue-specific Patterns of Chloramphenicol Acetyl Transferase Expression in Transgenic Mice.
H. Westphal, P.A. Overbeek, J.S. Khillan, A.B. Chepelinsky, A. Schmidt, K.A. Mahon, K.E. Bernstein, J. Piatigorsky, and B. de Crombrugghe (1985)
Cold Spring Harb Symp Quant Biol 50, 411-416
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)