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Science 4 January 1985:
Vol. 227. no. 4682, pp. 74 - 77
DOI: 10.1126/science.3964960
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Articles

Science, Vol 227, Issue 4682, 74-77
Copyright © 1985 by American Association for the Advancement of Science

articles

Selective loss of a family of gene transcripts in a hereditary murine cataract

AT Garber, C Winkler, T Shinohara, CR King, G Inana, J Piatigorsky, and RJ Gold

The eye lens of the Fraser mouse contains a dominantly inherited cataract with reduced amounts of seven distinct but homologous gamma crystallins encoded by a family of gamma-crystallin genes. The results of experiments with cultured lenses, cell-free RNA translation, and Northern blot hybridization indicated a specific loss of the family of gamma-crystallin messenger RNA's in the Fraser mouse lens. Southern blot hybridization of genomic DNA's from normal and Fraser mice showed no differences in gamma-crystallin coding sequences.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
{gamma}E-crystallin Recruitment to the Plasma Membrane by Specific Interaction between Lens MIP/Aquaporin-0 and {gamma}E-crystallin.
J. Fan, A. K. Donovan, D. R. Ledee, P. S. Zelenka, R. N. Fariss, and A. B. Chepelinsky (2004)
Invest. Ophthalmol. Vis. Sci. 45, 863-871
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Science. ISSN 0036-8075 (print), 1095-9203 (online)