Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 4 January 1985:
Vol. 227. no. 4682, pp. 65 - 67
DOI: 10.1126/science.2578071
Prev | Table of Contents | Next

Articles

Science, Vol 227, Issue 4682, 65-67
Copyright © 1985 by American Association for the Advancement of Science

articles

Two distinct populations of calcium channels in a clonal line of pituitary cells

CM Armstrong and DR Matteson

The whole-cell variant of the patch clamp technique was used to study calcium channels in GH3 cells. Two distinct populations of calcium channels, first recognized from their closing kinetics, were observed. The slowly closing channels are activated in a relatively negative voltage range and are inactivated within 100 milliseconds. They conduct barium and calcium about equally well. The fast closing channels are activated at more positive voltages, are not inactivated during a 100-millisecond pulse, conduct barium in preference to calcium, and are activated slightly more rapidly than the slowly closing channels.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Mibefradil Derivative NNC55-0396, a Specific T-Type Calcium Channel Antagonist, Exhibits Less CYP3A4 Inhibition than Mibefradil.
P. H. Bui, A. Quesada, A. Handforth, and O. Hankinson (2008)
Drug Metab. Dispos. 36, 1291-1299
   Abstract »    Full Text »    PDF »
The C. elegans T-type calcium channel CCA-1 boosts neuromuscular transmission.
K. A. Steger, B. B. Shtonda, C. Thacker, T. P. Snutch, and L. Avery (2005)
J. Exp. Biol. 208, 2191-2203
   Abstract »    Full Text »    PDF »
Exposure to cAMP and {beta}-adrenergic stimulation recruits CaV3 T-type channels in rat chromaffin cells through Epac cAMP-receptor proteins.
M. Novara, P. Baldelli, D. Cavallari, V. Carabelli, A. Giancippoli, and E. Carbone (2004)
J. Physiol. 558, 433-449
   Abstract »    Full Text »    PDF »
Multiple Structural Elements Contribute to the Slow Kinetics of the Cav3.3 T-type Channel.
J.-Y. Park, H.-W. Kang, S.-W. Jeong, and J.-H. Lee (2004)
J. Biol. Chem. 279, 21707-21713
   Abstract »    Full Text »    PDF »
NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-Benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: A New Selective Inhibitor of T-Type Calcium Channels.
L. Huang, B. M. Keyser, T. M. Tagmose, J. B. Hansen, J. T. Taylor, H. Zhuang, M. Zhang, D. S. Ragsdale, and M. Li (2004)
J. Pharmacol. Exp. Ther. 309, 193-199
   Abstract »    Full Text »
Molecular Physiology of Low-Voltage-Activated T-type Calcium Channels.
E. Perez-Reyes (2003)
Physiol Rev 83, 117-161
   Abstract »    Full Text »    PDF »
Differences in Apparent Pore Sizes of Low and High Voltage-activated Ca2+ Channels.
M. Cataldi, E. Perez-Reyes, and R. W. Tsien (2002)
J. Biol. Chem. 277, 45969-45976
   Abstract »    Full Text »    PDF »
Neuronal T-type alpha 1H Calcium Channels Induce Neuritogenesis and Expression of High-Voltage-Activated Calcium Channels in the NG108-15 Cell Line.
J. Chemin, J. Nargeot, and P. Lory (2002)
J. Neurosci. 22, 6856-6862
   Abstract »    Full Text »    PDF »
Specific contribution of human T-type calcium channel isotypes ({alpha}1G, {alpha}1H and {alpha}1I) to neuronal excitability.
J. Chemin, A. Monteil, E. Perez-Reyes, E. Bourinet, J. Nargeot, and P. Lory (2002)
J. Physiol. 540, 3-14
   Abstract »    Full Text »    PDF »
Gating Kinetics of the {alpha}1i T-Type Calcium Channel.
C. J. Frazier, J. R. Serrano, E. G. George, X. Yu, A. Viswanathan, E. Perez-Reyes, and S. W. Jones (2001)
J. Gen. Physiol. 118, 457-470
   Abstract »    Full Text »    PDF »
Rhythmic Bursts of Calcium Transients in Acute Anterior Pituitary Slices.
X. Bonnefont, J. Fiekers, A. Creff, and P. Mollard (2000)
Endocrinology 141, 868-875
   Abstract »    Full Text »    PDF »
The effect of {alpha}2-{delta} and other accessory subunits on expression and properties of the calcium channel {alpha}1G.
A C Dolphin, C N Wyatt, J Richards, R E Beattie, P Craig, J-H Lee, L L Cribbs, S G Volsen, and E Perez-Reyes (1999)
J. Physiol. 519, 35-45
   Abstract »    Full Text »    PDF »
Studies on Maitotoxin-Induced Intracellular Ca2+ Elevation in Chinese Hamster Ovary Cells Stably Transfected with cDNAs Encoding for L-Type Ca2+ Channel Subunits.
M. Cataldi, A. Secondo, A. D'Alessio, M. Taglialatela, F. Hofmann, N. Klugbauer, G. Di Renzo, and L. Annunziato (1999)
J. Pharmacol. Exp. Ther. 290, 725-730
   Abstract »    Full Text »
State-Dependent Inactivation of the {alpha}1g T-Type Calcium Channel.
J. R. Serrano, E. Perez-Reyes, and S. W. Jones (1999)
J. Gen. Physiol. 114, 185-202
   Abstract »    Full Text »    PDF »
Modulation of Iron Uptake in Heart by L-Type Ca2+ Channel Modifiers : Possible Implications in Iron Overload.
R. G. Tsushima, A. D. Wickenden, R. A. Bouchard, G. Y. Oudit, P. P. Liu, and P. H. Backx (1999)
Circ. Res. 84, 1302-1309
   Abstract »    Full Text »    PDF »
Biochemical and Electrophysiological Studies on the Mechanism of Action of PNU-151774E, A Novel Antiepileptic Compound.
P. Salvati, R. Maj, C. Caccia, M. A. Cervini, M. G. Fornaretto, E. Lamberti, P. Pevarello, G. A. Skeen, H. S. White, H. H. Wolf, et al. (1999)
J. Pharmacol. Exp. Ther. 288, 1151-1159
   Abstract »    Full Text »
Low-Voltage-Activated Ca2+ Currents Are Generated by Members of the CavT Subunit Family (alpha 1G/H) in Rat Primary Sensory Neurons.
R. C. Lambert, F. McKenna, Y. Maulet, E. M. Talley, D. A. Bayliss, L. L. Cribbs, J.-H. Lee, E. Perez-Reyes, and A. Feltz (1998)
J. Neurosci. 18, 8605-8613
   Abstract »    Full Text »    PDF »
Antisense oligonucleotides against alpha 1E reduce R-type calcium currents in cerebellar granule cells.
E. S. Piedras-Renteria and R. W. Tsien (1998)
PNAS 95, 7760-7765
   Abstract »    Full Text »    PDF »
Endogenous pacemaker activity of rat tumour somatotrophs.
R. Kwiecien, C. Robert, R. Cannon, S. Vigues, A. Arnoux, C. Kordon, and C. Hammond (1998)
J. Physiol. 508, 883-905
   Abstract »    Full Text »    PDF »
R-type Ca2+ currents evoke transmitter release at a rat central synapse.
L.-G. Wu, J. G. G. Borst, and B. Sakmann (1998)
PNAS 95, 4720-4725
   Abstract »    Full Text »    PDF »
Sphingosine Inhibits Voltage-operated Calcium Channels in GH4C1 Cells.
A. Titievsky, I. Titievskaya, M. Pasternack, K. Kaila, and K. Tornquist (1998)
J. Biol. Chem. 273, 242-247
   Abstract »    Full Text »    PDF »
Pharmacological Properties of T-Type Ca2+ Current in Adult Rat Sensory Neurons: Effects of Anticonvulsant and Anesthetic Agents.
S. M. Todorovic and C. J. Lingle (1998)
J Neurophysiol 79, 240-252
   Abstract »    Full Text »    PDF »
Neurotensin and Substance P Inhibit Low- and High-Voltage-Activated Ca2+ Channels in Cultured Newborn Rat Nucleus Basalis Neurons.
M. Margeta-Mitrovic, J. J. Grigg, K. Koyano, Y. Nakajima, and S. Nakajima (1997)
J Neurophysiol 78, 1341-1352
   Abstract »    Full Text »    PDF »
T-Type Ca2+ Current Properties Are Not Modified by Ca2+ Channel beta  Subunit Depletion in Nodosus Ganglion Neurons.
R. C. Lambert, Y. Maulet, J. Mouton, R. Beattie, S. Volsen, M. De Waard, and A. Feltz (1997)
J. Neurosci. 17, 6621-6628
   Abstract »    Full Text »    PDF »
Mibefradil: A New Selective T-Channel Calcium Antagonist for Hypertension and Angina Pectoris.
W. H. Frishman (1997)
Journal of Cardiovascular Pharmacology and Therapeutics 2, 321-330
   Abstract »    PDF »
Multiple Channel Types Contribute to the Low-Voltage-Activated Calcium Current in Hippocampal CA3 Pyramidal Neurons.
R. B. Avery and D. Johnston (1996)
J. Neurosci. 16, 5567-5582
   Abstract »    Full Text »    PDF »
Protein-tyrosine Kinases Activate while Protein-tyrosine Phosphatases Inhibit L-type Calcium Channel Activity in Pituitary GH(3) Cells.
M. Cataldi, M. Taglialatela, S. Guerriero, S. Amoroso, G. Lombardi, G. di Renzo, and L. Annunziato (1996)
J. Biol. Chem. 271, 9441-9446
   Abstract »    Full Text »    PDF »
Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes.
L Juntti-Berggren, O Larsson, P Rorsman, C Ammala, K Bokvist, K Wahlander, P Nicotera, J Dypbukt, S Orrenius, A Hallberg, et al. (1993)
Science 261, 86-90
   Abstract »    PDF »
Structure and functional expression of a member of the low voltage-activated calcium channel family.
T. Soong, A Stea, C. Hodson, S. Dubel, Vincent SR, and T. Snutch (1993)
Science 260, 1133-1136
   Abstract »    PDF »
Contributions of two types of calcium channels to synaptic transmission and plasticity.
B Edmonds, M Klein, N Dale, and E. Kandel (1990)
Science 250, 1142-1147
   Abstract »    PDF »
Structure and function of voltage-sensitive ion channels.
W. Catterall (1988)
Science 242, 50-61
   Abstract »    PDF »
Voltage-sensitive calcium channels in normal and transformed 3T3 fibroblasts.
C. Chen, M. Corbley, T. Roberts, and P Hess (1988)
Science 239, 1024-1026
   Abstract »    PDF »
Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons.
L. Hirning, A. Fox, E. McCleskey, B. Olivera, S. Thayer, R. Miller, and R. Tsien (1988)
Science 239, 57-61
   Abstract »    PDF »
Identification of an alpha subunit of dihydropyridine-sensitive brain calcium channels.
M Takahashi and W. Catterall (1987)
Science 236, 88-91
   Abstract »    PDF »
Multiple calcium channels and neuronal function.
R. Miller (1987)
Science 235, 46-52
   Abstract »    PDF »
Calcium and sodium channels in spontaneously contracting vascular muscle cells.
M Sturek and K Hermsmeyer (1986)
Science 233, 475-478
   Abstract »    PDF »
Expression and modulation of voltage-gated calcium channels after RNA injection in Xenopus oocytes.
N Dascal, T. Snutch, H Lubbert, N Davidson, and H. Lester (1986)
Science 231, 1147-1150
   Abstract »    PDF »
Regulation of L-type Calcium Channels in Pituitary GH4C1 Cells by Depolarization.
R. Peri, D. J. Triggle, and S. Singh (2001)
J. Biol. Chem. 276, 31667-31673
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)