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Science 4 January 1985:
Vol. 227. no. 4682, pp. 15 - 20
DOI: 10.1126/science.3843807
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Articles

Science, Vol 227, Issue 4682, 15-20
Copyright © 1985 by American Association for the Advancement of Science

articles

A new role for DNA virus early proteins in viral carcinogenesis

AM Lewis Jr and JL Cook

The T antigen proteins encoded by DNA tumor virus early genes are involved in the transformation of normal cells to immortalized neoplastic cells that may or may not be tumorigenic in immunocompetent animals. Studies have been made of the tumorigenicity of DNA virus-transformed cells and the interactions of these cells in vivo and in vitro with immunologically nonspecific host effector cells such as natural killer cells and macrophages. The results imply that the T proteins determine the capacity of transformed cells to induce tumors by governing the level of susceptibility that transformed cells express to destruction by such host cellular defenses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection.
J. M. Routes, S. Ryan, K. Morris, R. Takaki, A. Cerwenka, and L. L. Lanier (2005)
J. Exp. Med. 202, 1477-1482
   Abstract »    Full Text »    PDF »
Macrophages Kill Human Papillomavirus Type 16 E6-Expressing Tumor Cells by Tumor Necrosis Factor Alpha- and Nitric Oxide-Dependent Mechanisms.
J. M. Routes, K. Morris, M. C. Ellison, and S. Ryan (2005)
J. Virol. 79, 116-123
   Abstract »    Full Text »    PDF »
Histocompatibility antigens on murine tumors.
R. Goodenow, J. Vogel, and R. Linsk (1985)
Science 230, 777-783
   Abstract »    PDF »


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