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Science 21 December 1984:
Vol. 226. no. 4681, pp. 1439 - 1441
DOI: 10.1126/science.6334364
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Articles

Science, Vol 226, Issue 4681, 1439-1441
Copyright © 1984 by American Association for the Advancement of Science

articles

Induction of interleukin 2 messenger RNA inhibited by cyclosporin A

JF Elliott, Y Lin, SB Mizel, RC Bleackley, DG Harnish, and V Paetkau

Cyclosporin A blocked production of the lymphokine interleukin 2 by activated T lymphocytes. In a human and a murine cell line this inhibition reflected an absence of interleukin 2 messenger RNA. Under conditions in which these cells are normally stimulated to secrete high levels of interleukin 2, they failed to do so in the presence of cyclosporin A. In both cell lines this failure was accompanied by an absence of interleukin 2 messenger accumulation.


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