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Science 21 December 1984:
Vol. 226. no. 4681, pp. 1415 - 1418
DOI: 10.1126/science.6505699
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Articles

Science, Vol 226, Issue 4681, 1415-1418
Copyright © 1984 by American Association for the Advancement of Science

articles

High-resolution proton nuclear magnetic resonance analysis of metastatic cancer cells

CE Mountford, LC Wright, KT Holmes, WB Mackinnon, P Gregory, and RM Fox

High-resolution proton nuclear magnetic resonance (NMR) studies of intact cancer cells revealed differences between cells with the capacity to metastasize and those that produce locally invasive tumors. The NMR resonances that characterize the metastatic cells were associated with an increased ratio of cholesterol to phospholipid and an increased amount of plasma membrane-bound cholesterol ester. High-resolution NMR spectroscopy could therefore be used to assess the metastatic potential of primary tumors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Proton Magnetic Resonance Spectral Patterns of Metastasizing and Nonmetastasizing Human Colon Cancers.
W. Chen, J. W. Frazer, L. Dennis, C. M. McBride, and A. W. Boddie Jr (1987)
Arch Surg 122, 1284-1288
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