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Science 14 December 1984:
Vol. 226. no. 4680, pp. 1344 - 1345
DOI: 10.1126/science.226.4680.1344
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Articles

Amino-Terminal Amino Acid Sequence of the Silkworm Prothoracicotropic Hormone: Homology with Insulin

HIROMICHI NAGASAWA 1, HIROSHI KATAOKA 1, AKIRA ISOGAI 1, SABURO TAMURA 1, AKINORI SUZUKI 1, HIRONORI ISHIZAKI 2, AKIRA MIZOGUCHI 2, YUKO FUJIWARA 2, and ATSUSHI SUZUKI 2

1 Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan
2 Biological Institute, Nagoya University, Chikusa-ku, Nagoya 464, Japan

Three molecular forms of prothoracicotropic hormone were isolated from the head of the adult silkworm, Bombyx mori, and the amino acid sequence of 19 amino acid residues in the amino terminus of these prothoracicotropic hormones was determined. These residues exhibit significant homology with insulin and insulin-like growth factors.

Submitted on June 15, 1984
Accepted on August 15, 1984


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