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Science 14 December 1984:
Vol. 226. no. 4680, pp. 1342 - 1344
DOI: 10.1126/science.6334362

Articles

Science, Vol 226, Issue 4680, 1342-1344
Copyright © 1984 by American Association for the Advancement of Science


articles

Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients

CB Nemeroff, E Widerlov, G Bissette, H Walleus, I Karlsson, K Eklund, CD Kilts, PT Loosen, and W Vale

The possibility that hypersecretion of corticotropin-releasing factor (CRF) contributes to the hyperactivity of the hypothalamo-pituitary-adrenal axis observed in patients with major depression was investigated by measuring the concentration of this peptide in cerebrospinal fluid of normal healthy volunteers and in drug-free patients with DSM-III diagnoses of major depression, schizophrenia, or dementia. When compared to the controls and the other diagnostic groups, the patients with major depression showed significantly increased cerebrospinal fluid concentrations of CRF-like immunoreactivity; in 11 of the 23 depressed patients this immunoreactivity was greater than the highest value in the normal controls. These findings are concordant with the hypothesis that CRF hypersecretion is, at least in part, responsible for the hyperactivity of the hypothalamo-pituitary-adrenal axis characteristic of major depression.


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