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Science 14 December 1984:
Vol. 226. no. 4680, pp. 1339 - 1342
DOI: 10.1126/science.6390681
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Articles

Science, Vol 226, Issue 4680, 1339-1342
Copyright © 1984 by American Association for the Advancement of Science

articles

Purified human granulocyte-macrophage colony-stimulating factor: direct action on neutrophils

JC Gasson, RH Weisbart, SE Kaufman, SC Clark, RM Hewick, GG Wong, and DW Golde

Neutrophil migration inhibition factor from T lymphocytes (NIF-T) is a lymphokine that acts to localize granulocytes. Medium conditioned by the Mo human T-lymphoblast cell line was used to purify NIF-T, a glycoprotein with a molecular weight of 22,000. The NIF-T was found to potently stimulate the growth of granulocyte and macrophage colonies from human bone marrow and colony formation by the KG-1 myeloid leukemia cell line. Thus a human lymphokine (NIF-T) that modulates the activities of mature neutrophilic granulocytes is also a colony-stimulating factor acting on precursors to induce growth and differentiation of new effector cells.


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The human gene encoding GM-CSF is at 5q21-q32, the chromosome region deleted in the 5q- anomaly.
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