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Science 14 December 1984:
Vol. 226. no. 4680, pp. 1326 - 1328
DOI: 10.1126/science.6390680
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Articles

Science, Vol 226, Issue 4680, 1326-1328
Copyright © 1984 by American Association for the Advancement of Science

articles

Essential role of insulin in transcription of the rat 25,000 molecular weight casein gene

P Chomczynski, P Qasba, and YJ Topper

Insulin is essential for the accumulation of rat casein messenger RNA (mRNA) in the presence of glucocorticoid and prolactin. The accumulation of certain mRNA's in other tissues has also been linked to insulin action. The present study shows that the accumulation effect on the 25,000 molecular weight rat casein mRNA does not reflect stabilization of the transcript by insulin. Rather, insulin is essential for its synthesis in the presence of glucocorticoid and prolactin.


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