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Science 14 December 1984:
Vol. 226. no. 4680, pp. 1325 - 1326
DOI: 10.1126/science.6505692
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Articles

Science, Vol 226, Issue 4680, 1325-1326
Copyright © 1984 by American Association for the Advancement of Science

articles

Monoclonal idiotope vaccine against Streptococcus pneumoniae infection

MK McNamara, RE Ward, and H Kohler

A monoclonal anti-idiotope antibody coupled to a carrier protein was used to immunize BALB/c mice against a lethal Streptococcus pneumoniae infection. Vaccinated mice developed a high titer of antibody to phosphorylcholine, which is known to protect against infection with Streptococcus pneumoniae. Measurement of the median lethal dose of the bacteria indicated that anti-idiotope immunization significantly increased the resistance of BALB/c mice to the bacterial challenge. Antibody to an idiotope can thus be used as an antigen substitute for the induction of protective immunity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Protective Immunization against Group B Meningococci Using Anti-Idiotypic Mimics of the Capsular Polysaccharide.
C. Beninati, S. Arseni, G. Mancuso, W. Magliani, S. Conti, A. Midiri, C. Biondo, L. Polonelli, and G. Teti (2004)
J. Immunol. 172, 2461-2468
   Abstract »    Full Text »    PDF »
Pathogenesis of pneumococcal infection.
S.H. GILLESPIE and I. BALAKRISHNAN (2000)
J. Med. Microbiol. 49, 1057-1067
   Abstract »    Full Text »    PDF »
Peptide Mimic of Phosphorylcholine, a Dominant Epitope Found on Streptococcus pneumoniae.
S. L. Harris, M. K. Park, M. H. Nahm, and B. Diamond (2000)
Infect. Immun. 68, 5778-5784
   Abstract »    Full Text »    PDF »
Pneumococcal Diversity: Considerations for New Vaccine Strategies with Emphasis on Pneumococcal Surface Protein A (PspA).
D. E. Briles, R. C. Tart, E. Swiatlo, J. P. Dillard, P. Smith, K. A. Benton, B. A. Ralph, A. Brooks-Walter, M. J. Crain, S. K. Hollingshead, et al. (1998)
Clin. Microbiol. Rev. 11, 645-657
   Abstract »    Full Text »    PDF »
Peptides That Mimic the Group B Streptococcal Type III Capsular Polysaccharide Antigen.
S. H. Pincus, M. J. Smith, H. J. Jennings, J. B. Burritt, and P. M. Glee (1998)
J. Immunol. 160, 293-298
   Abstract »    Full Text »    PDF »
A hamster anti-idiotype monoclonal antibody, mimicking the inner-core region of Gram-negative bacterial lipopolysaccharide (LPS), stimulates LPS inner-core-specific serum antibodies in hamsters.
S.K. Field and D.C. Morrison (1994)
Innate Immunity 1, 120-130
   Abstract »    PDF »
High Incidence Rates of Invasive Pneumococcal Disease in the White Mountain Apache Population.
M. M. Cortese, M. Wolff, J. Almeido-Hill, R. Reid, J. Ketcham, and M. Santosham (1992)
Arch Intern Med 152, 2277-2282
   Abstract »    PDF »
The Specific Pathogen-Free Human: a New Frontier in Oral Infectious Disease Research.
M.A. Taubman, R.J. Genco, and J.D. Hillman (1989)
Advances in Dental Research 3, 58-68
   Abstract »    PDF »
Anti-idiotypic Antibodies as Vaccine Candidates: The Immune Network.
M. J. Rico and R. P. Hall III (1989)
Arch Dermatol 125, 271-275
   Abstract »    PDF »
Anti-idiotypic antibody vaccine for type B viral hepatitis in chimpanzees.
R. Kennedy, J. Eichberg, R. Lanford, and G. Dreesman (1986)
Science 232, 220-223
   Abstract »    PDF »


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