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Science 14 December 1984:
Vol. 226. no. 4680, pp. 1322 - 1325
DOI: 10.1126/science.6095452
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Articles

Science, Vol 226, Issue 4680, 1322-1325
Copyright © 1984 by American Association for the Advancement of Science

articles

Persistence of the entire Epstein-Barr virus genome integrated into human lymphocyte DNA

T Matsuo, M Heller, L Petti, E O'Shiro, and E Kieff

The entire Epstein-Barr virus genome is integrated into Burkitt tumor cell DNA at the terminal direct repeat sequence of the virus. There is no homology between the GC-rich (G, guanine; C, cytosine) terminal repeat and the AT-rich (A, adenine; T, thymine) cell sequences with which it has recombined. More than 15 kilobases of cell DNA have been deleted and 236 base pairs are duplicated at one virus-cell junction site.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Validation of Roche LightCycler Epstein-Barr Virus Quantification Reagents in a Clinical Laboratory Setting.
M. L. Gulley, H. Fan, and S. H. Elmore (2006)
J. Mol. Diagn. 8, 589-597
   Abstract »    Full Text »    PDF »
Integration of Epstein-Barr Virus into Chromosome 6q15 of Burkitt Lymphoma Cell Line (Raji) Induces Loss of BACH2 Expression.
T. Takakuwa, W.-J. Luo, M. F. Ham, F. Sakane-Ishikawa, N. Wada, and K. Aozasa (2004)
Am. J. Pathol. 164, 967-974
   Abstract »    Full Text »    PDF »
The EBV nuclear antigen 1 (EBNA1) enhances B cell immortalization several thousandfold.
S. Humme, G. Reisbach, R. Feederle, H.-J. Delecluse, K. Bousset, W. Hammerschmidt, and A. Schepers (2003)
PNAS 100, 10989-10994
   Abstract »    Full Text »    PDF »
EBNA3A Association with RBP-J{kappa} Down-Regulates c-myc and Epstein-Barr Virus-Transformed Lymphoblast Growth.
A. Cooper, E. Johannsen, S. Maruo, E. Cahir-McFarland, D. Illanes, D. Davidson, and E. Kieff (2002)
J. Virol. 77, 999-1010
   Abstract »    Full Text »    PDF »
Epstein-Barr Virus Promotes Epithelial Cell Growth in the Absence of EBNA2 and LMP1 Expression.
J. Nishikawa, S. Imai, T. Oda, T. Kojima, K. Okita, and K. Takada (1999)
J. Virol. 73, 1286-1292
   Abstract »    Full Text »
The Epstein-Barr Virus Major Latent Promoter Qp Is Constitutively Active, Hypomethylated, and Methylation Sensitive.
Q. Tao, K. D. Robertson, A. Manns, A. Hildesheim, and R. F. Ambinder (1998)
J. Virol. 72, 7075-7083
   Abstract »    Full Text »    PDF »
Deletion in chromosome 11p associated with a hepatitis B integration site in hepatocellular carcinoma.
C. Rogler, M Sherman, C. Su, D. Shafritz, J Summers, T. Shows, A Henderson, and M Kew (1985)
Science 230, 319-322
   Abstract »    PDF »
A second nuclear protein is encoded by Epstein-Barr virus in latent infection.
K Hennessy and E Kieff (1985)
Science 227, 1238-1240
   Abstract »    PDF »
Epstein-Barr virus nuclear antigen 1 activates transcription from episomal but not integrated DNA and does not alter lymphocyte growth.
M.-S. Kang, S. C. Hung, and E. Kieff (2001)
PNAS 98, 15233-15238
   Abstract »    Full Text »    PDF »


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