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Science 14 December 1984:
Vol. 226. no. 4680, pp. 1270 - 1277
DOI: 10.1126/science.6505691
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Articles

Science, Vol 226, Issue 4680, 1270-1277
Copyright © 1984 by American Association for the Advancement of Science

articles

Intrinsic mechanisms of pain inhibition: activation by stress

GW Terman, Y Shavit, JW Lewis, JT Cannon, and JC Liebeskind

Portions of the brain stem seem normally to inhibit pain. In man and laboratory animals these brain areas and pathways from them to spinal sensory circuits can be activated by focal stimulation. Endogenous opioids appear to be implicated although separate nonopioid mechanisms are also evident. Stress seems to be a natural stimulus triggering pain suppression. Properties of electric footshock have been shown to determine the opioid or nonopioid basis of stress-induced analgesia. Two different opioid systems can be activated by different footshock paradigms. This dissection of stress analgesia has begun to integrate divergent findings concerning pain inhibition and also to account for some of the variance that has obscured the reliable measurement of the effects of stress on tumor growth and immune function.


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