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Science 7 December 1984:
Vol. 226. no. 4679, pp. 1206 - 1209
DOI: 10.1126/science.6542248
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Articles

Science, Vol 226, Issue 4679, 1206-1209
Copyright © 1984 by American Association for the Advancement of Science

articles

Nucleotide sequences of the human and mouse atrial natriuretic factor genes

CE Seidman, KD Bloch, KA Klein, JA Smith, and JG Seidman

Mouse and human atrial natriuretic factor (ANF) genes have been cloned and their nucleotide sequences determined. Each ANF gene consists of three coding blocks separated by two intervening sequences. The 5' flanking sequences and those encoding proANF are highly conserved between the two species, while the intervening sequences and 3' untranslated regions are not. The conserved sequences 5' of the gene may play an important role in the regulation of ANF gene expression.


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