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Science 7 December 1984:
Vol. 226. no. 4679, pp. 1204 - 1206
DOI: 10.1126/science.6505687
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Articles

Science, Vol 226, Issue 4679, 1204-1206
Copyright © 1984 by American Association for the Advancement of Science

articles

The long terminal repeat sequences of a novel human endogenous retrovirus

CD O'Connell and M Cohen

The complete nucleotide sequence of both the 5' and 3' long terminal repeats (LTR's) has been determined for a human endogenous retroviral genome. These sequences are 593 and 590 nucleotides long and have diverged from one another by 8.8 percent. The LTR's resemble those of functional mammalian type C retroviruses in length and in the presence and location of eukaryotic promoter sequences. The 5' LTR is followed by a presumptive primer binding site unlike that of any known mammalian type C retrovirus, exhibiting 17 out of 18 nucleotides complementary to arginine transfer RNA rather than proline transfer RNA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification and Characterization of Novel Human Endogenous Retrovirus Families by Phylogenetic Screening of the Human Genome Mapping Project Database.
M. Tristem (2000)
J. Virol. 74, 3715-3730
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Selection of functional tRNA primers and primer binding site sequences from a retroviral combinatorial library: identification of new functional tRNA primers in murine leukemia virus replication.
A. H. Lund, M. Duch, and F. S. Pedersen (2000)
Nucleic Acids Res. 28, 791-799
   Abstract »    Full Text »    PDF »
Human Endogenous Retroviral Sequences: Possible Roles in Reproductive Physiopathology.
D. Taruscio and A. Mantovani (1998)
Biol Reprod 59, 713-724
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Transmission of Human T-Cell Leukemia Virus Type 1 to Mice.
J. Fang, S. Kushida, R. Feng, M. Tanaka, T. Kawamura, H. Abe, N. Maeda, M. Onobori, M. Hori, K. Uchida, et al. (1998)
J. Virol. 72, 3952-3957
   Abstract »    Full Text »    PDF »
Expression of endogenous retroviruses in blood mononuclear cells and brain tissue from multiple sclerosis patients.
H. Rasmussen, C Geny, L Deforges, H Perron, W Tourtelotte, A Heltberg, and J Clausen (1995)
Multiple Sclerosis 1, 82-87
   Abstract »    PDF »


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