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Science 7 December 1984:
Vol. 226. no. 4679, pp. 1199 - 1204
DOI: 10.1126/science.6239375
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Articles

Science, Vol 226, Issue 4679, 1199-1204
Copyright © 1984 by American Association for the Advancement of Science

articles

Constitutive fragile sites and cancer

JJ Yunis and AL Soreng

Breaks were observed at 51 sites in homologous chromosomes in lymphocytes from ten humans and two great apes when cells were deprived of thymidine. The incidence of breaks was enhanced by caffeine, a substance that inhibits DNA repair in replicating cells. The locations of 20 sites were correlated with breakpoints that have been related to human malignancy.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reduced Levels of DNA Polymerase {delta} Induce Chromosome Fragile Site Instability in Yeast.
F. J. Lemoine, N. P. Degtyareva, R. J. Kokoska, and T. D. Petes (2008)
Mol. Cell. Biol. 28, 5359-5368
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FRA18C: a new aphidicolin-inducible fragile site on chromosome 18q22, possibly associated with in vivo chromosome breakage.
K. Debacker, B. Winnepenninckx, N. Ben-Porat, D. FitzPatrick, R. Van Luijk, S. Scheers, B. Kerem, and R Frank Kooy (2007)
J. Med. Genet. 44, 347-352
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A palindrome-driven complex rearrangement of 22q11.2 and 8q24.1 elucidated using novel technologies.
A. L. Gotter, M. A. Nimmakayalu, G. R. Jalali, A. M. Hacker, J. Vorstman, D. Conforto Duffy, L. Medne, and B. S. Emanuel (2007)
Genome Res. 17, 470-481
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Inhibition of Breast Cancer Cell Growth In vitro and In vivo: Effect of Restoration of Wwox Expression.
D. Iliopoulos, M. Fabbri, T. Druck, H. R. Qin, S.-Y. Han, and K. Huebner (2007)
Clin. Cancer Res. 13, 268-274
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Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes.
A. Helmrich, K. Stout-Weider, K. Hermann, E. Schrock, and T. Heiden (2006)
Genome Res. 16, 1222-1230
   Abstract »    Full Text »    PDF »
Premature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites.
E. El Achkar, M. Gerbault-Seureau, M. Muleris, B. Dutrillaux, and M. Debatisse (2005)
PNAS 102, 18069-18074
   Abstract »    Full Text »    PDF »
Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability.
M. Schwartz, E. Zlotorynski, M. Goldberg, E. Ozeri, A. Rahat, C. l. Sage, B. P.C. Chen, D. J. Chen, R. Agami, and B. Kerem (2005)
Genes & Dev. 19, 2715-2726
   Abstract »    Full Text »    PDF »
Mechanisms of common fragile site instability.
T. W. Glover, M. F. Arlt, A. M. Casper, and S. G. Durkin (2005)
Hum. Mol. Genet. 14, R197-R205
   Abstract »    Full Text »    PDF »
Common chromosomal fragile site FRA16D mutation in cancer cells.
M. Finnis, S. Dayan, L. Hobson, G. Chenevix-Trench, K. Friend, K. Ried, D. Venter, E. Woollatt, E. Baker, and R. I. Richards (2005)
Hum. Mol. Genet. 14, 1341-1349
   Abstract »    Full Text »    PDF »
A Prospective Study of Dietary Folate Intake and Risk of Colorectal Cancer: Modification by Caffeine Intake and Cigarette Smoking.
S. C. Larsson, E. Giovannucci, and A. Wolk (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 740-743
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Components of DNA Damage Checkpoint Pathway Regulate UV Exposure-Dependent Alterations of Gene Expression of FHIT and WWOX at Chromosome Fragile Sites.
H. Ishii, K. Mimori, T. Inageta, Y. Murakumo, A. Vecchione, M. Mori, and Y. Furukawa (2005)
Mol. Cancer Res. 3, 130-138
   Abstract »    Full Text »    PDF »
SMC1 involvement in fragile site expression.
A. Musio, C. Montagna, T. Mariani, M. Tilenni, M. L. Focarelli, L. Brait, E. Indino, P. A. Benedetti, L. Chessa, A. Albertini, et al. (2005)
Hum. Mol. Genet. 14, 525-533
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Chromosomal Instability in Oral Cancer Cells.
S.C. Reshmi and S.M. Gollin (2005)
Journal of Dental Research 84, 107-117
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A palindrome-mediated mechanism distinguishes translocations involving LCR-B of chromosome 22q11.2.
A. L. Gotter, T. H. Shaikh, M. L. Budarf, C. H. Rhodes, and B. S. Emanuel (2004)
Hum. Mol. Genet. 13, 103-115
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Primer on Medical Genomics Part XI: Visualizing Human Chromosomes.
J. L. Spurbeck, S. A. Adams, P. J. Stupca, and G. W. Dewald (2004)
Mayo Clin. Proc. 79, 58-75
   Abstract »    PDF »
Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: Evolutionarily conserved but highly recombinogenic.
A. Matsuyama, T. Shiraishi, F. Trapasso, T. Kuroki, H. Alder, M. Mori, K. Huebner, and C. M. Croce (2003)
PNAS 100, 14988-14993
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Expression of FRA16D/WWOX and FRA3B/FHIT Genes in Hematopoietic Malignancies.
H. Ishii, A. Vecchione, Y. Furukawa, K. Sutheesophon, S.-Y. Han, T. Druck, T. Kuroki, F. Trapasso, M. Nishimura, Y. Saito, et al. (2003)
Mol. Cancer Res. 1, 940-947
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Molecular Basis for Expression of Common and Rare Fragile Sites.
E. Zlotorynski, A. Rahat, J. Skaug, N. Ben-Porat, E. Ozeri, R. Hershberg, A. Levi, S. W. Scherer, H. Margalit, and B. Kerem (2003)
Mol. Cell. Biol. 23, 7143-7151
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Chromosome 2 (2p16) abnormalities in Carney complex tumours.
L Matyakhina, S Pack, L S Kirschner, E Pak, P Mannan, J Jaikumar, S E Taymans, F Sandrini, J A Carney, and C A Stratakis (2003)
J. Med. Genet. 40, 268-277
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Distinct Amplification of an Untranslated Regulatory Sequence in the egfr Gene Contributes to Early Steps in Breast Cancer Development.
N. Tidow, A. Boecker, H. Schmidt, K. Agelopoulos, W. Boecker, H. Buerger, and B. Brandt (2003)
Cancer Res. 63, 1172-1178
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Nutritional and Genetic Inefficiencies in One-Carbon Metabolism and Cervical Cancer Risk.
R. G. Ziegler, S. J. Weinstein, and T. R. Fears (2002)
J. Nutr. 132, 2345S-2349
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Identification of Unstable Sequences within the Common Fragile Site at 3p14.2: Implications for the Mechanism of Deletions within Fragile Histidine Triad Gene/Common Fragile Site at 3p14.2 in Tumors.
S. Corbin, M. E. Neilly, R. Espinosa III, E. M. Davis, T. W. McKeithan, and M. M. Le Beau (2002)
Cancer Res. 62, 3477-3484
   Abstract »    Full Text »    PDF »
Enhanced flexibility and aphidicolin-induced DNA breaks near mammalian replication origins: implications for replicon mapping and chromosome fragility.
F. Toledo, A. Coquelle, E. Svetlova, and M. Debatisse (2000)
Nucleic Acids Res. 28, 4805-4813
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Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells.
K. Ried, M. Finnis, L. Hobson, M. Mangelsdorf, S. Dayan, J. K. Nancarrow, E. Woollatt, G. Kremmidiotis, A. Gardner, D. Venter, et al. (2000)
Hum. Mol. Genet. 9, 1651-1663
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Replication Delay along FRA7H, a Common Fragile Site on Human Chromosome 7, Leads to Chromosomal Instability.
A. Hellman, A. Rahat, S. W. Scherer, A. Darvasi, L.-C. Tsui, and B. Kerem (2000)
Mol. Cell. Biol. 20, 4420-4427
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Chromosomal Fragile Site FRA16D and DNA Instability in Cancer.
M. Mangelsdorf, K. Ried, E. Woollatt, S. Dayan, H. Eyre, M. Finnis, L. Hobson, J. Nancarrow, D. Venter, E. Baker, et al. (2000)
Cancer Res. 60, 1683-1689
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Colorectal Cancer: Molecules and Populations.
J. D. Potter (1999)
J Natl Cancer Inst 91, 916-932
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Role of FHIT in Human Cancer.
C. M. Croce, G. Sozzi, and K. Huebner (1999)
J. Clin. Oncol. 17, 1618
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Chromosome breakage at sites of oncogenes in a population accidentally exposed to radioactive chemical pollution.
N. N. Ilyinskikh, I. N. Ilyinskikh, and E. N. Ilyinskikh (1999)
Mutagenesis 14, 83-86
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Direct cloning and analysis of DNA sequences from a region of the Chinese hamster genome associated with aphidicolin-sensitive fragility.
A. Palin, R Critcher, D. Fitzgerald, J. Anderson, and C. Farr (1998)
J. Cell Sci. 111, 1623-1634
   Abstract »    PDF »
Sequence of the FRA3B common fragile region: Implications for the mechanism of FHIT deletion.
H. Inoue, H. Ishii, H. Alder, E. Snyder, T. Druck, K. Huebner, and C. M. Croce (1997)
PNAS 94, 14584-14589
   Abstract »    Full Text »    PDF »
Folate Deficiency and Cervical Dysplasia.
C. E. Butterworth Jr, K. D. Hatch, M. Macaluso, P. Cole, H. E. Sauberlich, S.-J. Soong, M. Borst, and V. V. Baker (1992)
JAMA 267, 528-533
   Abstract »    PDF »
The human as an experimental system in molecular genetics.
R White and C. Caskey (1988)
Science 240, 1483-1488
   Abstract »    PDF »
Improvement in Bronchial Squamous Metaplasia in Smokers Treated With Folate and Vitamin B12: Report of a Preliminary Randomized, Double-blind Intervention Trial.
D. C. Heimburger, C. B. Alexander, R. Birch, C. E. Butterworth Jr, W. C. Bailey, and C. L. Krumdieck (1988)
JAMA 259, 1525-1530
   Abstract »    PDF »
The fragile X site in somatic cell hybrids: an approach for molecular cloning of fragile sites.
S. Warren, F Zhang, G. Licameli, and J. Peters (1987)
Science 237, 420-423
   Abstract »    PDF »
Fragile sites at 16q22 are not at the breakpoint of the chromosomal rearrangement in AMMoL.
R. Simmers, G. Sutherland, A West, and R. Richards (1987)
Science 236, 92-94
   Abstract »    PDF »
A novel human gene closely related to the abl proto-oncogene.
G. Kruh, C. King, M. Kraus, N. Popescu, S. Amsbaugh, W. McBride, and S. Aaronson (1986)
Science 234, 1545-1548
   Abstract »    PDF »
Common mechanism of chromosome inversion in B- and T-cell tumors: relevance to lymphoid development.
C. Denny, G. Hollis, F Hecht, R Morgan, M. Link, S. Smith, and I. Kirsch (1986)
Science 234, 197-200
   Abstract »    PDF »
Molecular analysis of the t(2;14) translocation of childhood chronic lymphocytic leukemia.
H. Fell, R. Smith, and P. Tucker (1986)
Science 232, 491-494
   Abstract »    PDF »
Hu-ets-1 and Hu-ets-2 genes are transposed in acute leukemias with (4;11) and (8;21) translocations.
N Sacchi, D. Watson, A. Guerts van Kessel, A Hagemeijer, J Kersey, H. Drabkin, D Patterson, and T. Papas (1986)
Science 231, 379-382
   Abstract »    PDF »
Localization of the gene encoding the human interleukin-2 receptor on chromosome 10.
W. Leonard, T. Donlon, R. Lebo, and W. Greene (1985)
Science 228, 1547-1549
   Abstract »    PDF »
FHIT gene therapy prevents tumor development in Fhit-deficient mice.
K. R. Dumon, H. Ishii, L. Y. Y. Fong, N. Zanesi, V. Fidanza, R. Mancini, A. Vecchione, R. Baffa, F. Trapasso, M. J. During, et al. (2001)
PNAS 98, 3346-3351
   Abstract »    Full Text »    PDF »
Muir-Torre-like syndrome in Fhit-deficient mice.
L. Y. Y. Fong, V. Fidanza, N. Zanesi, L. F. Lock, L. D. Siracusa, R. Mancini, Z. Siprashvili, M. Ottey, S. E. Martin, T. Druck, et al. (2000)
PNAS 97, 4742-4747
   Abstract »    Full Text »    PDF »


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