Science 7 December 1984: Vol. 226. no. 4679, pp. 1199 - 1204 DOI: 10.1126/science.6239375

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Articles

Reduced Levels of DNA Polymerase {delta} Induce Chromosome Fragile Site Instability in Yeast.

F. J. Lemoine, N. P. Degtyareva, R. J. Kokoska, and T. D. Petes (2008)
Mol. Cell. Biol. 28, 5359-5368
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FRA18C: a new aphidicolin-inducible fragile site on chromosome 18q22, possibly associated with in vivo chromosome breakage.

K. Debacker, B. Winnepenninckx, N. Ben-Porat, D. FitzPatrick, R. Van Luijk, S. Scheers, B. Kerem, and R Frank Kooy (2007)
J. Med. Genet. 44, 347-352
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A palindrome-driven complex rearrangement of 22q11.2 and 8q24.1 elucidated using novel technologies.

A. L. Gotter, M. A. Nimmakayalu, G. R. Jalali, A. M. Hacker, J. Vorstman, D. Conforto Duffy, L. Medne, and B. S. Emanuel (2007)
Genome Res. 17, 470-481
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Inhibition of Breast Cancer Cell Growth In vitro and In vivo: Effect of Restoration of Wwox Expression.

D. Iliopoulos, M. Fabbri, T. Druck, H. R. Qin, S.-Y. Han, and K. Huebner (2007)
Clin. Cancer Res. 13, 268-274
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Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes.

A. Helmrich, K. Stout-Weider, K. Hermann, E. Schrock, and T. Heiden (2006)
Genome Res. 16, 1222-1230
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Premature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites.

E. El Achkar, M. Gerbault-Seureau, M. Muleris, B. Dutrillaux, and M. Debatisse (2005)
PNAS 102, 18069-18074
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Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability.

M. Schwartz, E. Zlotorynski, M. Goldberg, E. Ozeri, A. Rahat, C. l. Sage, B. P.C. Chen, D. J. Chen, R. Agami, and B. Kerem (2005)
Genes & Dev. 19, 2715-2726
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Mechanisms of common fragile site instability.

T. W. Glover, M. F. Arlt, A. M. Casper, and S. G. Durkin (2005)
Hum. Mol. Genet. 14, R197-R205
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Common chromosomal fragile site FRA16D mutation in cancer cells.

M. Finnis, S. Dayan, L. Hobson, G. Chenevix-Trench, K. Friend, K. Ried, D. Venter, E. Woollatt, E. Baker, and R. I. Richards (2005)
Hum. Mol. Genet. 14, 1341-1349
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A Prospective Study of Dietary Folate Intake and Risk of Colorectal Cancer: Modification by Caffeine Intake and Cigarette Smoking.

S. C. Larsson, E. Giovannucci, and A. Wolk (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 740-743
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Components of DNA Damage Checkpoint Pathway Regulate UV Exposure-Dependent Alterations of Gene Expression of FHIT and WWOX at Chromosome Fragile Sites.

H. Ishii, K. Mimori, T. Inageta, Y. Murakumo, A. Vecchione, M. Mori, and Y. Furukawa (2005)
Mol. Cancer Res. 3, 130-138
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SMC1 involvement in fragile site expression.

A. Musio, C. Montagna, T. Mariani, M. Tilenni, M. L. Focarelli, L. Brait, E. Indino, P. A. Benedetti, L. Chessa, A. Albertini, et al. (2005)
Hum. Mol. Genet. 14, 525-533
 |  Abstract »  |  Full Text »  |  PDF »

Chromosomal Instability in Oral Cancer Cells.

S.C. Reshmi and S.M. Gollin (2005)
J. Dent. Res. 84, 107-117
 |  Abstract »  |  Full Text »  |  PDF »

A palindrome-mediated mechanism distinguishes translocations involving LCR-B of chromosome 22q11.2.

A. L. Gotter, T. H. Shaikh, M. L. Budarf, C. H. Rhodes, and B. S. Emanuel (2004)
Hum. Mol. Genet. 13, 103-115
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Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: Evolutionarily conserved but highly recombinogenic.

A. Matsuyama, T. Shiraishi, F. Trapasso, T. Kuroki, H. Alder, M. Mori, K. Huebner, and C. M. Croce (2003)
PNAS 100, 14988-14993
 |  Abstract »  |  Full Text »  |  PDF »

Expression of FRA16D/WWOX and FRA3B/FHIT Genes in Hematopoietic Malignancies.

H. Ishii, A. Vecchione, Y. Furukawa, K. Sutheesophon, S.-Y. Han, T. Druck, T. Kuroki, F. Trapasso, M. Nishimura, Y. Saito, et al. (2003)
Mol. Cancer Res. 1, 940-947
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Basis for Expression of Common and Rare Fragile Sites.

E. Zlotorynski, A. Rahat, J. Skaug, N. Ben-Porat, E. Ozeri, R. Hershberg, A. Levi, S. W. Scherer, H. Margalit, and B. Kerem (2003)
Mol. Cell. Biol. 23, 7143-7151
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Chromosome 2 (2p16) abnormalities in Carney complex tumours.

L Matyakhina, S Pack, L S Kirschner, E Pak, P Mannan, J Jaikumar, S E Taymans, F Sandrini, J A Carney, and C A Stratakis (2003)
J. Med. Genet. 40, 268-277
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Distinct Amplification of an Untranslated Regulatory Sequence in the egfr Gene Contributes to Early Steps in Breast Cancer Development.

N. Tidow, A. Boecker, H. Schmidt, K. Agelopoulos, W. Boecker, H. Buerger, and B. Brandt (2003)
Cancer Res. 63, 1172-1178
 |  Abstract »  |  Full Text »  |  PDF »

Nutritional and Genetic Inefficiencies in One-Carbon Metabolism and Cervical Cancer Risk.

R. G. Ziegler, S. J. Weinstein, and T. R. Fears (2002)
J. Nutr. 132, 2345S-2349
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Unstable Sequences within the Common Fragile Site at 3p14.2: Implications for the Mechanism of Deletions within Fragile Histidine Triad Gene/Common Fragile Site at 3p14.2 in Tumors.

S. Corbin, M. E. Neilly, R. Espinosa III, E. M. Davis, T. W. McKeithan, and M. M. Le Beau (2002)
Cancer Res. 62, 3477-3484
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced flexibility and aphidicolin-induced DNA breaks near mammalian replication origins: implications for replicon mapping and chromosome fragility.

F. Toledo, A. Coquelle, E. Svetlova, and M. Debatisse (2000)
Nucleic Acids Res. 28, 4805-4813
 |  Abstract »  |  Full Text »  |  PDF »

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells.

K. Ried, M. Finnis, L. Hobson, M. Mangelsdorf, S. Dayan, J. K. Nancarrow, E. Woollatt, G. Kremmidiotis, A. Gardner, D. Venter, et al. (2000)
Hum. Mol. Genet. 9, 1651-1663
 |  Abstract »  |  Full Text »  |  PDF »

Replication Delay along FRA7H, a Common Fragile Site on Human Chromosome 7, Leads to Chromosomal Instability.

A. Hellman, A. Rahat, S. W. Scherer, A. Darvasi, L.-C. Tsui, and B. Kerem (2000)
Mol. Cell. Biol. 20, 4420-4427
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Chromosomal Fragile Site FRA16D and DNA Instability in Cancer.

M. Mangelsdorf, K. Ried, E. Woollatt, S. Dayan, H. Eyre, M. Finnis, L. Hobson, J. Nancarrow, D. Venter, E. Baker, et al. (2000)
Cancer Res. 60, 1683-1689
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Colorectal Cancer: Molecules and Populations.

J. D. Potter (1999)
J Natl Cancer Inst 91, 916-932
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Role of FHIT in Human Cancer.

C. M. Croce, G. Sozzi, and K. Huebner (1999)
J. Clin. Oncol. 17, 1618
 |  Abstract »  |  Full Text »  |  PDF »

Chromosome breakage at sites of oncogenes in a population accidentally exposed to radioactive chemical pollution.

N. N. Ilyinskikh, I. N. Ilyinskikh, and E. N. Ilyinskikh (1999)
Mutagenesis 14, 83-86
 |  Abstract »  |  Full Text »  |  PDF »

Direct cloning and analysis of DNA sequences from a region of the Chinese hamster genome associated with aphidicolin-sensitive fragility.

A. Palin, R Critcher, D. Fitzgerald, J. Anderson, and C. Farr (1998)
J. Cell Sci. 111, 1623-1634
 |  Abstract »  |  PDF »

Sequence of the FRA3B common fragile region: Implications for the mechanism of FHIT deletion.

H. Inoue, H. Ishii, H. Alder, E. Snyder, T. Druck, K. Huebner, and C. M. Croce (1997)
PNAS 94, 14584-14589
 |  Abstract »  |  Full Text »  |  PDF »

The human as an experimental system in molecular genetics.

R White and C. Caskey (1988)
Science 240, 1483-1488
 |  Abstract »  |  PDF »

The fragile X site in somatic cell hybrids: an approach for molecular cloning of fragile sites.

S. Warren, F Zhang, G. Licameli, and J. Peters (1987)
Science 237, 420-423
 |  Abstract »  |  PDF »

Fragile sites at 16q22 are not at the breakpoint of the chromosomal rearrangement in AMMoL.

R. Simmers, G. Sutherland, A West, and R. Richards (1987)
Science 236, 92-94
 |  Abstract »  |  PDF »

A novel human gene closely related to the abl proto-oncogene.

G. Kruh, C. King, M. Kraus, N. Popescu, S. Amsbaugh, W. McBride, and S. Aaronson (1986)
Science 234, 1545-1548
 |  Abstract »  |  PDF »

Common mechanism of chromosome inversion in B- and T-cell tumors: relevance to lymphoid development.

C. Denny, G. Hollis, F Hecht, R Morgan, M. Link, S. Smith, and I. Kirsch (1986)
Science 234, 197-200
 |  Abstract »  |  PDF »

Molecular analysis of the t(2;14) translocation of childhood chronic lymphocytic leukemia.

H. Fell, R. Smith, and P. Tucker (1986)
Science 232, 491-494
 |  Abstract »  |  PDF »

Hu-ets-1 and Hu-ets-2 genes are transposed in acute leukemias with (4;11) and (8;21) translocations.

N Sacchi, D. Watson, A. Guerts van Kessel, A Hagemeijer, J Kersey, H. Drabkin, D Patterson, and T. Papas (1986)
Science 231, 379-382
 |  Abstract »  |  PDF »

Localization of the gene encoding the human interleukin-2 receptor on chromosome 10.

W. Leonard, T. Donlon, R. Lebo, and W. Greene (1985)
Science 228, 1547-1549
 |  Abstract »  |  PDF »

FHIT gene therapy prevents tumor development in Fhit-deficient mice.

K. R. Dumon, H. Ishii, L. Y. Y. Fong, N. Zanesi, V. Fidanza, R. Mancini, A. Vecchione, R. Baffa, F. Trapasso, M. J. During, et al. (2001)
PNAS 98, 3346-3351
 |  Abstract »  |  Full Text »  |  PDF »

Muir-Torre-like syndrome in Fhit-deficient mice.

L. Y. Y. Fong, V. Fidanza, N. Zanesi, L. F. Lock, L. D. Siracusa, R. Mancini, Z. Siprashvili, M. Ottey, S. E. Martin, T. Druck, et al. (2000)
PNAS 97, 4742-4747
 |  Abstract »  |  Full Text »  |  PDF »

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