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Science 30 November 1984:
Vol. 226. no. 4678, pp. 1087 - 1089
DOI: 10.1126/science.6494925
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Articles

Science, Vol 226, Issue 4678, 1087-1089
Copyright © 1984 by American Association for the Advancement of Science

articles

Autoimmunity and increased c-myb transcription

JD Mountz, AD Steinberg, DM Klinman, HR Smith, and JF Mushinski

A single recessive gene, lpr, induces an autoimmune-lymphoproliferative syndrome in several strains of mice. The lymphoid organs of lpr/lpr mice contained cells with increased amounts of myb RNA, which codes for a protein found in the nucleus. A similar human lymphoproliferative disorder also had an increase in c-myb expression. Mouse T cells induced by mitogens to proliferate did not express large amounts of myb RNA, indicating that marked myb expression is not a general feature of lymphocyte activation and proliferation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A dominant interfering Myb mutant causes apoptosis in T cells..
D Taylor, P Badiani, and K Weston (1996)
Genes & Dev. 10, 2732-2744
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Interleukin-2 induction of T-cell G1 progression and c-myb expression.
J. Stern and K. Smith (1986)
Science 233, 203-206
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