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Science 30 November 1984:
Vol. 226. no. 4678, pp. 1085 - 1087
DOI: 10.1126/science.6093262
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Articles

Science, Vol 226, Issue 4678, 1085-1087
Copyright © 1984 by American Association for the Advancement of Science

articles

Beta-adrenergic mechanism of insulin-induced adrenocorticotropin release from the anterior pituitary

E Mezey, TD Reisine, MJ Brownstein, M Palkovits, and J Axelrod

Intraperitoneal administration of insulin to control rats and to rats with pituitary stalk transections or with lesions of the median eminence resulted in increased plasma adrenocorticotropin (ACTH) levels. The insulin-induced stimulation of ACTH release was blocked in both the control and lesioned animals by prior treatment with either the beta-adrenergic antagonist propranolol or the glucocorticoid analog dexamethasone. The direct application of insulin to primary cultures of the anterior pituitary did not evoke ACTH release or affect the maximal ability of corticotropin-releasing factor or epinephrine to stimulate ACTH secretion. The results suggest that insulin stimulates ACTH release by a mechanism in which catecholamines of peripheral origin act directly on the anterior pituitary.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Stressor Specificity of Central Neuroendocrine Responses: Implications for Stress-Related Disorders.
K. Pacak and M. Palkovits (2001)
Endocr. Rev. 22, 502-548
   Abstract »    Full Text »    PDF »
The sympathochromaffin system and the pituitary-adrenocortical response to hypoglycemia.
P. E CRYER (1986)
Science 231, 501-502
   PDF »


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