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Science 30 November 1984:
Vol. 226. no. 4678, pp. 1080 - 1082
DOI: 10.1126/science.6093261
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Articles

Science, Vol 226, Issue 4678, 1080-1082
Copyright © 1984 by American Association for the Advancement of Science

articles

Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor

BH Cochran, J Zullo, IM Verma, and CD Stiles

Complementary DNA clones of genes induced by platelet-derived growth factor (PDGF) in BALB/c-3T3 cells were isolated; one such clone contains a domain having nucleotide sequence homology with the third exon of c-fos. This nucleotide sequence homology is reflected in the predicted amino acid sequences of the gene products. Under low stringency conditions, the mouse v-fos gene cross-hybridizes with the PDGF-inducible complementary DNA clone. However, the messenger RNA transcripts of mouse c-fos and the new fos-related gene can be distinguished by gel electrophoresis and by S1 nuclease analysis. Expression of the authentic c-fos gene is induced by PDGF and superinduced by the combination of PDGF and cycloheximide.


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