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Science 30 November 1984:
Vol. 226. no. 4678, pp. 1077 - 1080
DOI: 10.1126/science.6093260
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Articles

Science, Vol 226, Issue 4678, 1077-1080
Copyright © 1984 by American Association for the Advancement of Science

articles

Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas

GL Shen-Ong, M Potter, JF Mushinski, S Lavu, and EP Reddy

Rearrangement in the c-myb locus of each of four independently derived BALB/c plasmacytoid lymphosarcoma (ABPL's) is due to the insertion of a defective Moloney murine leukemia virus (M-MuLV) into a 1.5-kilobase-pair stretch of cellular DNA at the 5' end of the v-myb-related sequences. This retroviral insertion is associated with abnormal transcription of myb sequences and probably represents a step in the neoplastic transformation of ABPL cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children.
E. Clappier, W. Cuccuini, A. Kalota, A. Crinquette, J.-M. Cayuela, W. A. Dik, A. W. Langerak, B. Montpellier, B. Nadel, P. Walrafen, et al. (2007)
Blood 110, 1251-1261
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Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis.
H. C. Hwang, C. P. Martins, Y. Bronkhorst, E. Randel, A. Berns, M. Fero, and B. E. Clurman (2002)
PNAS 99, 11293-11298
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A Novel Subgenomic Murine Leukemia Virus RNA Transcript Results from Alternative Splicing.
J. Déjardin, G. Bompard-Maréchal, M. Audit, T. J. Hope, M. Sitbon, and M. Mougel (2000)
J. Virol. 74, 3709-3714
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Introduction of a cis-Acting Mutation in the Capsid-Coding Gene of Moloney Murine Leukemia Virus Extends Its Leukemogenic Properties.
M. Audit, J. Déjardin, B. Hohl, C. Sidobre, T. J. Hope, M. Mougel, and M. Sitbon (1999)
J. Virol. 73, 10472-10479
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Anandamide, a Natural Ligand for the Peripheral Cannabinoid Receptor Is a Novel Synergistic Growth Factor for Hematopoietic Cells.
P. Valk, S. Verbakel, Y. Vankan, S. Hol, S. Mancham, R. Ploemacher, A. Mayen, B. Lowenberg, and R. Delwel (1997)
Blood 90, 1448-1457
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The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb..
A B Dash, F C Orrico, and S A Ness (1996)
Genes & Dev. 10, 1858-1869
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New light on Myc and Myb. Part II. Myb..
B Luscher and R N Eisenman (1990)
Genes & Dev. 4, 2235-2241
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Mutation of the core or adjacent LVb elements of the Moloney murine leukemia virus enhancer alters disease specificity..
N A Speck, B Renjifo, E Golemis, T N Fredrickson, J W Hartley, and N Hopkins (1990)
Genes & Dev. 4, 233-242
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Relationship between the c-myb locus and the 6q-chromosomal aberration in leukemias and lymphomas.
C Barletta, P. Pelicci, L. Kenyon, S. Smith, and R Dalla-Favera (1987)
Science 235, 1064-1067
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Studies of the human c-myb gene and its product in human acute leukemias.
D. Slamon, T. Boone, D. Murdock, D. Keith, M. Press, R. Larson, and L. Souza (1986)
Science 233, 347-351
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