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Science 30 November 1984:
Vol. 226. no. 4678, pp. 1077 - 1080
DOI: 10.1126/science.6093260
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Articles

Science, Vol 226, Issue 4678, 1077-1080
Copyright © 1984 by American Association for the Advancement of Science

articles

Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas

GL Shen-Ong, M Potter, JF Mushinski, S Lavu, and EP Reddy

Rearrangement in the c-myb locus of each of four independently derived BALB/c plasmacytoid lymphosarcoma (ABPL's) is due to the insertion of a defective Moloney murine leukemia virus (M-MuLV) into a 1.5-kilobase-pair stretch of cellular DNA at the 5' end of the v-myb-related sequences. This retroviral insertion is associated with abnormal transcription of myb sequences and probably represents a step in the neoplastic transformation of ABPL cells.


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Identification of oncogenes collaborating with p27Kip1 loss by insertional mutagenesis and high-throughput insertion site analysis.
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The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb..
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New light on Myc and Myb. Part II. Myb..
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Mutation of the core or adjacent LVb elements of the Moloney murine leukemia virus enhancer alters disease specificity..
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Relationship between the c-myb locus and the 6q-chromosomal aberration in leukemias and lymphomas.
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Studies of the human c-myb gene and its product in human acute leukemias.
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