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Science 23 November 1984:
Vol. 226. no. 4677, pp. 982 - 985
DOI: 10.1126/science.6505678
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Articles

Science, Vol 226, Issue 4677, 982-985
Copyright © 1984 by American Association for the Advancement of Science

articles

Modulation of the metastatic activity of melanoma cells by laminin and fibronectin

VP Terranova, JE Williams, LA Liotta, and GR Martin

Metastatic mouse melanoma cells have a high affinity for the basement membrane and the ability to degrade it; these properties may allow tumor cells to invade the membrane and disseminate. In this study it was found that the metastatic potential of mouse melanoma cells varied when the cells were exposed in culture to fibronectin or laminin. After removal of fibronectin or exposure to laminin, the cells had an increased affinity for basement membrane collagen, were more invasive of basement membranes in vitro, and produced more lung colonies in vivo. These changes are correlated with and may be due to an increase in the laminin-binding capacity of the tumor cell surface.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A multi-marker assay to distinguish malignant melanomas from benign nevi.
M. Kashani-Sabet, J. Rangel, S. Torabian, M. Nosrati, J. Simko, D. M. Jablons, D. H. Moore, C. Haqq, J. R. Miller III, and R. W. Sagebiel (2009)
PNAS 106, 6268-6272
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Acquired Melanocyte Stimulating Hormone-inducible Chemotaxis following Macrophage Fusion with Cloudman S91 Melanoma Cells.
M. Rachkovsky and J. Pawelek (1999)
Cell Growth Differ. 10, 517-524
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Murine Epidermal Growth Factor Peptide (33-42) Binds to a YIGSR-specific Laminin Receptor on both Tumor and Endothelial Cells.
J. Nelson, W. N. Scott, W. E. Allen, D. J. Wilson, P. Harriott, N. V. McFerran, and B. Walker (1996)
J. Biol. Chem. 271, 26179-26186
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Developmental regulation of integrin expression at the time of implantation in the mouse embryo.
A. E. Sutherland, P. G. Calarco, and C. H. Damsky (1993)
Development 119, 1175-1186
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In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells.
B. Chan, N Matsuura, Y Takada, B. Zetter, and M. Hemler (1991)
Science 251, 1600-1602
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An inducible endothelial cell surface glycoprotein mediates melanoma adhesion.
G. Rice and M. Bevilacqua (1989)
Science 246, 1303-1306
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Healing, Regeneration, and Repair: Prospectus for New Dental Treatment.
V.P. Terranova, M. Jendresen, and F. Young (1989)
Advances in Dental Research 3, 69-79
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YIGSR, a synthetic laminin pentapeptide, inhibits experimental metastasis formation.
Y Iwamoto, F. Robey, J Graf, M Sasaki, H. Kleinman, Y Yamada, and G. Martin (1987)
Science 238, 1132-1134
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A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells.
M. Humphries, K Olden, and K. Yamada (1986)
Science 233, 467-470
   Abstract »    PDF »
Presence of laminin receptors in Staphylococcus aureus.
J. Lopes, M dos Reis, and R. Brentani (1985)
Science 229, 275-277
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