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Science 23 November 1984:
Vol. 226. no. 4677, pp. 982 - 985
DOI: 10.1126/science.6505678
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Articles

Science, Vol 226, Issue 4677, 982-985
Copyright © 1984 by American Association for the Advancement of Science

articles

Modulation of the metastatic activity of melanoma cells by laminin and fibronectin

VP Terranova, JE Williams, LA Liotta, and GR Martin

Metastatic mouse melanoma cells have a high affinity for the basement membrane and the ability to degrade it; these properties may allow tumor cells to invade the membrane and disseminate. In this study it was found that the metastatic potential of mouse melanoma cells varied when the cells were exposed in culture to fibronectin or laminin. After removal of fibronectin or exposure to laminin, the cells had an increased affinity for basement membrane collagen, were more invasive of basement membranes in vitro, and produced more lung colonies in vivo. These changes are correlated with and may be due to an increase in the laminin-binding capacity of the tumor cell surface.


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