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Science 23 November 1984:
Vol. 226. no. 4677, pp. 979 - 982
DOI: 10.1126/science.6095446
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Articles

Science, Vol 226, Issue 4677, 979-982
Copyright © 1984 by American Association for the Advancement of Science

articles

A single troponin T gene regulated by different programs in cardiac and skeletal muscle development

TA Cooper and CP Ordahl

A cloned complementary DNA derived from a messenger RNA transiently present at low abundance levels in early chick embryonic skeletal muscle hybridizes to a messenger RNA present at high abundance levels in cardiac muscle. Genomic DNA hybridization and nucleotide sequence identity of complementary DNA's from both heart and skeletal muscle demonstrate that the messenger RNA's from both sources are encoded by the same gene. The encoded polypeptide is a troponin T sequence which is probably a cardiac isoform. This single copy troponin T isogene is governed by different regulatory programs in heart and skeletal muscle differentiation.


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Characterization of Troponin T Dilated Cardiomyopathy Mutations in the Fetal Troponin Isoform.
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Muscle-Specific Splicing of a Heterologous Exon Mediated by a Single Muscle-Specific Splicing Enhancer from the Cardiac Troponin T Gene.
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The Role of Transcription Enhancer Factor-1 (TEF-1) Related Proteins in the Formation of M-CAT Binding Complexes in Muscle and Non-muscle Tissues.
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