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Science 23 November 1984:
Vol. 226. no. 4677, pp. 974 - 977
DOI: 10.1126/science.6095445
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Articles

Science, Vol 226, Issue 4677, 974-977
Copyright © 1984 by American Association for the Advancement of Science

articles

Functional insertion of an Alu type 2 (B2 SINE) repetitive sequence in murine class I genes

M Kress, Y Barra, JG Seidman, G Khoury, and G Jay

The regulation of expression of the family of MHC (major histocompatibility complex) class I genes is complex. Sequence analysis has revealed that class I genes from the H-2D subregion of the MHC (which includes the D and L genes) differ from the class I gene from the H-2K subregion (the K gene) by the insertion of a type 2 Alu-like repetitive element (the murine B2 sequence) within the 3' noncoding region of the D and L genes. The consequence of this insertion in the D and L genes is the introduction of a novel polyadenylation signal, which is preferentially used over the more distal signal, the analog of that found in the K gene. The insertion of the type 2 Alu-like sequence results in a change in the preferred site for endonucleolytic cleavage which is necessary for generating a correct 3' terminus for polyadenylation. The data demonstrate that the type 2 Alu-like sequence has a function; the data also suggest a possible regulatory role of this sequence in the expression of class I genes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Histocompatibility antigens on murine tumors.
R. Goodenow, J. Vogel, and R. Linsk (1985)
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Reversal of oncogenesis by the expression of a major histocompatibility complex class I gene.
K Tanaka, K. Isselbacher, G Khoury, and G Jay (1985)
Science 228, 26-30
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