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Science 16 November 1984:
Vol. 226. no. 4676, pp. 860 - 862
DOI: 10.1126/science.6436980
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Articles

Science, Vol 226, Issue 4676, 860-862
Copyright © 1984 by American Association for the Advancement of Science

articles

Homologies between signal transducing G proteins and ras gene products

JB Hurley, MI Simon, DB Teplow, JD Robishaw, and AG Gilman

The guanosine triphosphate-binding proteins (G proteins) found in a variety of tissues transduce signals generated by ligand binding to cell surface receptors into changes in intracellular metabolism. Amino acid sequences of peptides prepared by partial proteolysis of the alpha subunit of a bovine brain G protein and the alpha subunit of rod outer-segment transducin were determined. The two proteins show regions of sequence identity as well as regions of diversity. A portion of the amino-terminal peptide sequence of each protein is highly homologous with the corresponding region in the ras protein (a protooncogene product). These similarities suggest that G proteins and ras proteins may have analogous functions.


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ras Oncogene Proteins: Three-dimensional Structures, Functional Implications, and a Model for Signal Transducer.
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The oncogenic activation of human p21ras by a novel mechanism.
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S Ishii, J. Kadonaga, R Tjian, J. Brady, G. Merlino, and I Pastan (1986)
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The action of oncogenes in the cytoplasm and nucleus.
R. Weinberg (1985)
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A model for the tertiary structure of p21, the product of the ras oncogene.
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