Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 9 November 1984:
Vol. 226. no. 4675, pp. 698 - 700
DOI: 10.1126/science.6494904
Prev | Table of Contents | Next

Articles

Science, Vol 226, Issue 4675, 698-700
Copyright © 1984 by American Association for the Advancement of Science

articles

Human ornithine transcarbamylase locus mapped to band Xp21.1 near the Duchenne muscular dystrophy locus

V Lindgren, B de Martinville, AL Horwich, LE Rosenberg, and U Francke

The gene for the mitochondrial enzyme ornithine transcarbamylase was mapped to the short arm of the X chromosome by in situ hybridization experiments, with DNA complementary to the human ornithine transcarbamylase gene used as a probe. A series of cell lines with X chromosome abnormalities was used to localize the gene to band Xp21.1. Because the gene maps near the Duchenne muscular dystrophy locus, the ornithine transcarbamylase probe may be useful in carrier detection and prenatal diagnosis of Duchenne muscular dystrophy as well as of ornithine transcarbamylase deficiency.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Fatal Initial Adult-Onset Presentation of Urea Cycle Defect.
J. Lien, W. L. Nyhan, and B. A. Barshop (2007)
Arch Neurol 64, 1777-1779
   Abstract »    Full Text »    PDF »
Electroencephalographic Findings in Ornithine Transcarbamylase Deficiency.
P. Brunquell, K. Tezcan, and F. J. DiMario JR (1999)
J Child Neurol 14, 533-536
   Abstract »    PDF »
Ornithine Transcarbamylase Deficiency in Females: An Often Overlooked Cause of Treatable Encephalopathy.
C. L. Pridmore, J. T.R. Clarke, and S. Blaser (1995)
J Child Neurol 10, 369-374
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)