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Science 2 November 1984:
Vol. 226. no. 4674, pp. 561 - 564
DOI: 10.1126/science.6093252
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Articles

Science, Vol 226, Issue 4674, 561-564
Copyright © 1984 by American Association for the Advancement of Science

articles

Serotonin selectively inhibits growth cone motility and synaptogenesis of specific identified neurons

PG Haydon, DP McCobb, and SB Kater

The motile activity of growth cones of specific identified neurons is inhibited by the neurotransmitter serotonin, although other identified neurons are unaffected. As a consequence, affected neurons are unable to form electrical synapses, whereas other neurons whose growth is unaffected can still interconnect. This result demonstrates that neurotransmitters can play a prominent role in regulating neuronal architecture and connectivity in addition to their classical role in neurotransmission.


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Competition among the Axonal Projections of an Identified Neuron Contributes to the Retraction of Some of Those Projections.
W.-B. Gan and E. R. Macagno (1997)
J. Neurosci. 17, 4293-4301
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Differential Distribution of Functional Receptors for Neuromodulators Evoking Short-Term Heterosynaptic Plasticity in Aplysia Sensory Neurons.
Z.-Y. Sun, B. Kauderer, and S. Schacher (1996)
J. Neurosci. 16, 7540-7549
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Activity-Independent Segregation of Excitatory and Inhibitory Synaptic Terminals in Cultured Hippocampal Neurons.
D. L. Benson and P. A. Cohen (1996)
J. Neurosci. 16, 6424-6432
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A Family of Rat CRMP Genes Is Differentially Expressed in the Nervous System.
L.-H. Wang and S. M. Strittmatter (1996)
J. Neurosci. 16, 6197-6207
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Signal Transduction at the Neuronal Growth Cone.
S. M. Strittmatter (1996)
Neuroscientist 2, 83-86
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An amino-terminal domain of the growth-associated protein GAP-43 mediates its effects on filopodial formation and cell spreading.
S. Strittmatter, D Valenzuela, and M. Fishman (1994)
J. Cell Sci. 107, 195-204
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Ventral spinal cord inhibition of neurite outgrowth from embryonic rat dorsal root ganglia.
M Fitzgerald, G. Kwiat, J Middleton, and A Pini (1993)
Development 117, 1377-1384
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Mediation by G proteins of signals that cause collapse of growth cones.
M Igarashi, S. Strittmatter, T Vartanian, and M. Fishman (1993)
Science 259, 77-79
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Role of intracellular calcium in NI-35-evoked collapse of neuronal growth cones.
C. Bandtlow, M. Schmidt, T. Hassinger, M. Schwab, and S. Kater (1993)
Science 259, 80-83
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Short-term Electrophysiological Actions of Insulin on Aplysia Neurons: Identification of a Possible Novel Modulatory Second-messenger Mechanism.
J.H. Schwartz, E. Shapiro, S.D. Brown, and A.R. Saltiel (1990)
Cold Spring Harb Symp Quant Biol 55, 95-100
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Neuronal Growth Cone as an Integrator of Complex Environmental Information.
S.B. Kater and P.B. Guthrie (1990)
Cold Spring Harb Symp Quant Biol 55, 359-370
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Isolation and characterization of Drosophila cAMP-dependent protein kinase genes..
D Kalderon and G M Rubin (1988)
Genes & Dev. 2, 1539-1556
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Growth cone guidance in insects: fasciclin II is a member of the immunoglobulin superfamily.
A. Harrelson and C. Goodman (1988)
Science 242, 700-708
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Neuronal cytomechanics: the actin-based motility of growth cones.
S. Smith (1988)
Science 242, 708-715
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Dynamic pattern generation in behavioral and neural systems.
G Schoner and J. Kelso (1988)
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Nicotinic antagonists enhance process outgrowth by rat retinal ganglion cells in culture.
S. Lipton, M. Frosch, M. Phillips, D. Tauck, and E Aizenman (1988)
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Suppression of neurite elongation and growth cone motility by electrical activity.
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