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Science 2 November 1984:
Vol. 226. no. 4674, pp. 557 - 559
DOI: 10.1126/science.226.4674.557
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Articles

Prophenoloxidase Activation: Nonself Recognition and Cell Cooperation in Insect Immunity

NORMAN A. RATCLIFFE 1, CATHERINE LEONARD 1, and ANDREW F. ROWLEY 1

1 Department of Zoology, University College of Swansea, Singleton Park, SA2 8PP, United Kingdom

The mechanism of nonself recognition by the immune system of insects is unknown. In this report the activation of the prophenoloxidase system in the wax moth Galleria mellonella by a microbial product is shown to enhance the recognition of nonself material. These results explain previous observations of the interaction of two different blood cell populations in the cellular defense reactions of insects.

Submitted on February 10, 1984
Accepted on June 15, 1984


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