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Science 2 November 1984:
Vol. 226. no. 4674, pp. 549 - 552
DOI: 10.1126/science.6093251
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Articles

Science, Vol 226, Issue 4674, 549-552
Copyright © 1984 by American Association for the Advancement of Science

articles

Transmission of HTLV-III infection from human plasma to chimpanzees: an animal model for AIDS

HJ Alter, JW Eichberg, H Masur, WC Saxinger, R Gallo, AM Macher, HC Lane, and AS Fauci

Two of three chimpanzees given plasma from patients with acquired immune deficiency syndrome (AIDS) or pre-AIDS showed serum antibodies to type III human T-cell leukemia virus (HTLV-III) 10 to 12 weeks after transfusion. One animal also developed lymphadenopathy, transient depression of the ratio of T4 to T8 lymphocytes, and impaired blastogenic responses. No opportunistic infections occurred. Adenopathy persisted for 32 weeks, and antibody to HTLV-III persisted for at least 48 weeks. This transmission of HTLV-III by lymphocyte-poor plasma confirms the potential risk of such plasma or plasma derivatives to recipients. The susceptibility of the chimpanzee to HTLV-III infection and the ability to simulate the human lymphadenopathy syndrome in this animal makes it a valuable model for further study of AIDS.


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