Science 2 November 1984: Vol. 226. no. 4674, pp. 544 - 547 DOI: 10.1126/science.6238408

Prev | Table of Contents | Next

Articles

Differential proteomic analysis of cyclosporine A-induced toxicity in renal proximal tubule cells.

M. Puigmule, J. Lopez-Hellin, G. Sune, O. Tornavaca, S. Camano, A. Tejedor, and A. Meseguer (2009)
Nephrol. Dial. Transplant. 24, 2672-2686
 |  Abstract »  |  Full Text »  |  PDF »

Cyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 Protein.

M. Qing, F. Yang, B. Zhang, G. Zou, J. M. Robida, Z. Yuan, H. Tang, and P.-Y. Shi (2009)
Antimicrob. Agents Chemother. 53, 3226-3235
 |  Abstract »  |  Full Text »  |  PDF »

Critical Role of Cyclophilin A and Its Prolyl-Peptidyl Isomerase Activity in the Structure and Function of the Hepatitis C Virus Replication Complex.

Z. Liu, F. Yang, J. M. Robotham, and H. Tang (2009)
J. Virol. 83, 6554-6565
 |  Abstract »  |  Full Text »  |  PDF »

The Isomerase Active Site of Cyclophilin A Is Critical for Hepatitis C Virus Replication.

U. Chatterji, M. Bobardt, S. Selvarajah, F. Yang, H. Tang, N. Sakamoto, G. Vuagniaux, T. Parkinson, and P. Gallay (2009)
J. Biol. Chem. 284, 16998-17005
 |  Abstract »  |  Full Text »  |  PDF »

Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolyl cis/trans Isomerase Activity of Cyclophilins A and B.

X. Hanoulle, A. Badillo, J.-M. Wieruszeski, D. Verdegem, I. Landrieu, R. Bartenschlager, F. Penin, and G. Lippens (2009)
J. Biol. Chem. 284, 13589-13601
 |  Abstract »  |  Full Text »  |  PDF »

Use of a Real-Time Fluorescence Monitoring System for High-Throughput Screening for Prolyl Isomerase Inhibitors.

T. Mori, S. Itami, T. Yanagi, Y. Tatara, M. Takamiya, and T. Uchida (2009)
J Biomol Screen 14, 419-424
 |  Abstract »  |  PDF »

Prolyl Isomerase Cyclophilin A Regulation of Janus-Activated Kinase 2 and the Progression of Human Breast Cancer.

J. Zheng, J. E. Koblinski, L. V. Dutson, Y. B. Feeney, and C. V. Clevenger (2008)
Cancer Res. 68, 7769-7778
 |  Abstract »  |  Full Text »  |  PDF »

Cyclophilin A Is an Essential Cofactor for Hepatitis C Virus Infection and the Principal Mediator of Cyclosporine Resistance In Vitro.

F. Yang, J. M. Robotham, H. B. Nelson, A. Irsigler, R. Kenworthy, and H. Tang (2008)
J. Virol. 82, 5269-5278
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Human Immunodeficiency Virus Type 1 Replication in Human Cells by Debio-025, a Novel Cyclophilin Binding Agent.

R. G. Ptak, P. A. Gallay, D. Jochmans, A. P. Halestrap, U. T. Ruegg, L. A. Pallansch, M. D. Bobardt, M.-P. de Bethune, J. Neyts, E. De Clercq, et al. (2008)
Antimicrob. Agents Chemother. 52, 1302-1317
 |  Abstract »  |  Full Text »  |  PDF »

Cyclophilin A Is Required for CXCR4-mediated Nuclear Export of Heterogeneous Nuclear Ribonucleoprotein A2, Activation and Nuclear Translocation of ERK1/2, and Chemotactic Cell Migration.

H. Pan, C. Luo, R. Li, A. Qiao, L. Zhang, M. Mines, A. M. Nyanda, J. Zhang, and G.-H. Fan (2008)
J. Biol. Chem. 283, 623-637
 |  Abstract »  |  Full Text »  |  PDF »

Structural and Functional Characterization of the Interaction between Cyclophilin B and a Heparin-derived Oligosaccharide.

X. Hanoulle, A. Melchior, N. Sibille, B. Parent, A. Denys, J.-M. Wieruszeski, D. Horvath, F. Allain, G. Lippens, and I. Landrieu (2007)
J. Biol. Chem. 282, 34148-34158
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of Human Cell Heterokaryons Demonstrates that Target Cell Restriction of Cyclosporine-Resistant Human Immunodeficiency Virus Type 1 Mutants Is Genetically Dominant.

C. Song and C. Aiken (2007)
J. Virol. 81, 11946-11956
 |  Abstract »  |  Full Text »  |  PDF »

The Heparin/Heparan Sulfate Sequence That Interacts with Cyclophilin B Contains a 3-O-Sulfated N-Unsubstituted Glucosamine Residue.

C. Vanpouille, A. Deligny, M. Delehedde, A. Denys, A. Melchior, X. Lienard, M. Lyon, J. Mazurier, D. G. Fernig, and F. Allain (2007)
J. Biol. Chem. 282, 24416-24429
 |  Abstract »  |  Full Text »  |  PDF »

Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia.

C. Zhu, X. Wang, J. Deinum, Z. Huang, J. Gao, N. Modjtahedi, M. R. Neagu, M. Nilsson, P. S. Eriksson, H. Hagberg, et al. (2007)
J. Exp. Med. 204, 1741-1748
 |  Abstract »  |  Full Text »  |  PDF »

Syndecan-1/CD147 association is essential for cyclophilin B-induced activation of p44/42 mitogen-activated protein kinases and promotion of cell adhesion and chemotaxis.

R. Pakula, A. Melchior, A. Denys, C. Vanpouille, J. Mazurier, and F. Allain (2007)
Glycobiology 17, 492-503
 |  Abstract »  |  Full Text »  |  PDF »

Overexpressed Cyclophilin A in Cancer Cells Renders Resistance to Hypoxia- and Cisplatin-Induced Cell Death.

K. J. Choi, Y. J. Piao, M. J. Lim, J. H. Kim, J. Ha, W. Choe, and S. S. Kim (2007)
Cancer Res. 67, 3654-3662
 |  Abstract »  |  Full Text »  |  PDF »

Cyclosporin A Abolishes CD28-Mediated Resistance to CD95-Induced Apoptosis via Superinduction of Caspase-3.

A. Kerstan, N. Armbruster, M. Leverkus, and T. Hunig (2006)
J. Immunol. 177, 7689-7697
 |  Abstract »  |  Full Text »  |  PDF »

Novel Approach to Inhibit Asthma-Mediated Lung Inflammation Using Anti-CD147 Intervention.

W. M. Gwinn, J. M. Damsker, R. Falahati, I. Okwumabua, A. Kelly-Welch, A. D. Keegan, C. Vanpouille, J. J. Lee, L. A. Dent, D. Leitenberg, et al. (2006)
J. Immunol. 177, 4870-4879
 |  Abstract »  |  Full Text »  |  PDF »

Induction of g2 arrest and binding to cyclophilin a are independent phenotypes of human immunodeficiency virus type 1 vpr..

O. Ardon, E. S. Zimmerman, J. L. Andersen, J. L. DeHart, J. Blackett, and V. Planelles (2006)
J. Virol. 80, 3694-3700
 |  Abstract »  |  Full Text »  |  PDF »

AtCyp59 is a multidomain cyclophilin from Arabidopsis thaliana that interacts with SR proteins and the C-terminal domain of the RNA polymerase II.

M. GULLEROVA, A. BARTA, and Z. J. LORKOVIC (2006)
RNA 12, 631-643
 |  Abstract »  |  Full Text »  |  PDF »

Stable RNA Interference-Mediated Suppression of Cyclophilin A Diminishes Non-Small-Cell Lung Tumor Growth In vivo.

B. A. Howard, R. Furumai, M. J. Campa, Z. N. Rabbani, Z. Vujaskovic, X.-F. Wang, and E. F. Patz Jr. (2005)
Cancer Res. 65, 8853-8860
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of Neospora caninum Cyclophilin That Elicits Gamma Interferon Production.

W. Tuo, R. Fetterer, M. Jenkins, and J. P. Dubey (2005)
Infect. Immun. 73, 5093-5100
 |  Abstract »  |  Full Text »  |  PDF »

Cyclophilin A Binds to Linear Peptide Motifs Containing a Consensus That Is Present in Many Human Proteins.

K. Piotukh, W. Gu, M. Kofler, D. Labudde, V. Helms, and C. Freund (2005)
J. Biol. Chem. 280, 23668-23674
 |  Abstract »  |  Full Text »  |  PDF »

Cyclophilin A-Deficient Mice Are Resistant to Immunosuppression by Cyclosporine.

J. Colgan, M. Asmal, B. Yu, and J. Luban (2005)
J. Immunol. 174, 6030-6038
 |  Abstract »  |  Full Text »  |  PDF »

The Ess1 prolyl isomerase is dispensable for growth but required for virulence in Cryptococcus neoformans.

P. Ren, A. Rossettini, V. Chaturvedi, and S. D. Hanes (2005)
Microbiology 151, 1593-1605
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Inhibitory Effects of Tacrolimus and Cyclosporin A on Calcineurin Phosphatase Activity.

M. Fukudo, I. Yano, S. Masuda, M. Okuda, and K.-i. Inui (2005)
J. Pharmacol. Exp. Ther. 312, 816-825
 |  Abstract »  |  Full Text »  |  PDF »

Cyclophilin A Is Localized to the Nucleus and Controls Meiosis in Saccharomyces cerevisiae.

M. Arevalo-Rodriguez and J. Heitman (2005)
Eukaryot. Cell 4, 17-29
 |  Abstract »  |  Full Text »  |  PDF »

Cyclosporin A produces distal renal tubular acidosis by blocking peptidyl prolyl cis-trans isomerase activity of cyclophilin.

S. Watanabe, S. Tsuruoka, S. Vijayakumar, G. Fischer, Y. Zhang, A. Fujimura, Q. Al-Awqati, and G. J. Schwartz (2005)
Am J Physiol Renal Physiol 288, F40-F47
 |  Abstract »  |  Full Text »  |  PDF »

Cyclophilin-A Is Bound through Its Peptidylprolyl Isomerase Domain to the Cytoplasmic Dynein Motor Protein Complex.

M. D. Galigniana, Y. Morishima, P. A. Gallay, and W. B. Pratt (2004)
J. Biol. Chem. 279, 55754-55759
 |  Abstract »  |  Full Text »  |  PDF »

Target Cell Cyclophilin A Modulates Human Immunodeficiency Virus Type 1 Infectivity.

E. Sokolskaja, D. M. Sayah, and J. Luban (2004)
J. Virol. 78, 12800-12808
 |  Abstract »  |  Full Text »  |  PDF »

FKBP12 Controls Aspartate Pathway Flux in Saccharomyces cerevisiae To Prevent Toxic Intermediate Accumulation.

M. Arevalo-Rodriguez, X. Pan, J. D. Boeke, and J. Heitman (2004)
Eukaryot. Cell 3, 1287-1296
 |  Abstract »  |  Full Text »  |  PDF »

Structural analysis uncovers a role for redox in regulating FKBP13, an immunophilin of the chloroplast thylakoid lumen.

G. Gopalan, Z. He, Y. Balmer, P. Romano, R. Gupta, A. Heroux, B. B. Buchanan, K. Swaminathan, and S. Luan (2004)
PNAS 101, 13945-13950
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of HIV-1 multiplication by antisense U7 snRNAs and siRNAs targeting cyclophilin A.

S. Liu, M. Asparuhova, V. Brondani, I. Ziekau, T. Klimkait, and D. Schumperli (2004)
Nucleic Acids Res. 32, 3752-3759
 |  Abstract »  |  Full Text »  |  PDF »

Roles of the C. elegans cyclophilin-like protein MOG-6 in MEP-1 binding and germline fates.

M. Belfiore, P. Pugnale, Z. Saudan, and A. Puoti (2004)
Development 131, 2935-2945
 |  Abstract »  |  Full Text »  |  PDF »

Cyclophilin A Is Required for Retinoic Acid-induced Neuronal Differentiation in p19 Cells.

J. Song, Y.-C. Lu, K. Yokoyama, J. Rossi, and R. Chiu (2004)
J. Biol. Chem. 279, 24414-24419
 |  Abstract »  |  Full Text »  |  PDF »

Introducing Immunophilins. From Organ Transplantation to Plant Biology.

P. Romano, Z. He, and S. Luan (2004)
Plant Physiology 134, 1241-1243
 |  Full Text »  |  PDF »

The Arabidopsis Cyclophilin Gene Family.

P. G.N. Romano, P. Horton, and J. E. Gray (2004)
Plant Physiology 134, 1268-1282
 |  Abstract »  |  Full Text »  |  PDF »

Chimeric Human Immunodeficiency Virus Type 1 (HIV-1) Virions Containing HIV-2 or Simian Immunodeficiency Virus Nef Are Resistant to Cyclosporine Treatment.

M. Khan, L. Jin, M. B. Huang, L. Miles, V. C. Bond, and M. D. Powell (2004)
J. Virol. 78, 1843-1850
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear antisense effects in cyclophilin A pre-mRNA splicing by oligonucleotides: a comparison of tricyclo-DNA with LNA.

D. Ittig, S. Liu, D. Renneberg, D. Schumperli, and C. J. Leumann (2004)
Nucleic Acids Res. 32, 346-353
 |  Abstract »  |  Full Text »  |  PDF »

Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression.

T. Chen, J. Guo, M. Yang, C. Han, M. Zhang, W. Chen, Q. Liu, J. Wang, and X. Cao (2004)
Blood 103, 413-421
 |  Abstract »  |  Full Text »  |  PDF »

Cyclophilin A Interacts with HIV-1 Vpr and Is Required for Its Functional Expression.

K. Zander, M. P. Sherman, U. Tessmer, K. Bruns, V. Wray, A. T. Prechtel, E. Schubert, P. Henklein, J. Luban, J. Neidleman, et al. (2003)
J. Biol. Chem. 278, 43202-43213
 |  Abstract »  |  Full Text »  |  PDF »

Redistribution of Cyclophilin A to Viral Factories during Vaccinia Virus Infection and Its Incorporation into Mature Particles.

A. P. V. Castro, T. M. U. Carvalho, N. Moussatche, and C. R. A. Damaso (2003)
J. Virol. 77, 9052-9068
 |  Abstract »  |  Full Text »  |  PDF »

Immunophilins, mTOR, and Pharmacodynamic Strategies for a Targeted Cancer Therapy: Commentary re: J. M. Peralba et al., Pharmacodynamic Evaluation of CCI-779, an Inhibitor of mTOR, in Cancer Patients. Clin. Cancer Res., 9: 2887-2892, 2003..

M. W. Harding (2003)
Clin. Cancer Res. 9, 2882-2886
 |  Full Text »  |  PDF »

Treatment of Human Immunodeficiency Virus Type 1 Virions Depleted of Cyclophilin A by Natural Endogenous Reverse Transcription Restores Infectivity.

M. Khan, M. Garcia-Barrio, and M. D. Powell (2003)
J. Virol. 77, 4431-4434
 |  Abstract »  |  Full Text »  |  PDF »

Differential Actions of Cardioprotective Agents on the Mitochondrial Death Pathway.

M. Akao, B. O'Rourke, H. Kusuoka, Y. Teshima, S. P. Jones, and E. Marban (2003)
Circ. Res. 92, 195-202
 |  Abstract »  |  Full Text »  |  PDF »

A Single-domain Cyclophilin from Leishmania donovani Reactivates Soluble Aggregates of Adenosine Kinase by Isomerase-independent Chaperone Function.

A. Chakraborty, I. Das, R. Datta, B. Sen, D. Bhattacharyya, C. Mandal, and A. K. Datta (2002)
J. Biol. Chem. 277, 47451-47460
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of Moca-cyp. A DROSOPHILA MELANOGASTER NUCLEAR CYCLOPHILIN.

L. Cavarec, T. Kamphausen, B. Dubourg, I. Callebaut, F. Lemeunier, D. Metivier, J. Feunteun, G. Fischer, and N. Modjtahedi (2002)
J. Biol. Chem. 277, 41171-41182
 |  Abstract »  |  Full Text »  |  PDF »

Cyclophilin A Peptidyl-Prolyl Isomerase Activity Promotes Zpr1 Nuclear Export.

H. Ansari, G. Greco, and J. Luban (2002)
Mol. Cell. Biol. 22, 6993-7003
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Cyclophilin from Parasitic and Free-living Nematodes with a Unique Substrate- and Drug-binding Domain.

D. Ma, L. S. Nelson, K. LeCoz, C. Poole, and C. K. S. Carlow (2002)
J. Biol. Chem. 277, 14925-14932
 |  Abstract »  |  Full Text »  |  PDF »

Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A.

D. A. Bosco, E. Z. Eisenmesser, S. Pochapsky, W. I. Sundquist, and D. Kern (2002)
PNAS 99, 5247-5252
 |  Abstract »  |  Full Text »  |  PDF »

Cyclophilin A Plays Distinct Roles in Human Immunodeficiency Virus Type 1 Entry and Postentry Events, as Revealed by Spinoculation.

A. C. S. Saphire, M. D. Bobardt, and P. A. Gallay (2002)
J. Virol. 76, 4671-4677
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Cell Cycle Progression by the Novel Cyclophilin Ligand Sanglifehrin A Is Mediated through the NFkappa B-dependent Activation of p53.

L.-H. Zhang, H.-D. Youn, and J. O. Liu (2001)
J. Biol. Chem. 276, 43534-43540
 |  Abstract »  |  Full Text »  |  PDF »

Vascular Smooth Muscle Growth: Autocrine Growth Mechanisms.

B. C. Berk (2001)
Physiol Rev 81, 999-1030
 |  Abstract »  |  Full Text »  |  PDF »

Sanglifehrin A, a Novel Cyclophilin-Binding Compound Showing Immunosuppressive Activity with a New Mechanism of Action.

G. Zenke, U. Strittmatter, S. Fuchs, V. F. J. Quesniaux, V. Brinkmann, W. Schuler, M. Zurini, A. Enz, A. Billich, J.-J. Sanglier, et al. (2001)
J. Immunol. 166, 7165-7171
 |  Abstract »  |  Full Text »  |  PDF »

Structural Consequences of Cyclophilin A Binding on Maturational Refolding in Human Immunodeficiency Virus Type 1 Capsid Protein.

L. Dietrich, L. S. Ehrlich, T. J. LaGrassa, D. Ebbets-Reed, and C. Carter (2001)
J. Virol. 75, 4721-4733
 |  Abstract »  |  Full Text »

Sanglifehrin A, a Novel Cyclophilin-Binding Immunosuppressant, Inhibits IL-2-Dependent T Cell Proliferation at the G1 Phase of the Cell Cycle.

L.-H. Zhang and J. O. Liu (2001)
J. Immunol. 166, 5611-5618
 |  Abstract »  |  Full Text »  |  PDF »

Cyclophilin A Is a Secreted Growth Factor Induced by Oxidative Stress.

Z.-G. Jin, M. G. Melaragno, D.-F. Liao, C. Yan, J. Haendeler, Y.-A. Suh, J. D. Lambeth, and B. C. Berk (2000)
Circ. Res. 87, 789-796
 |  Abstract »  |  Full Text »  |  PDF »

Possible Involvement of Cyclophilin B and Caspase-Activated Deoxyribonuclease in the Induction of Chromosomal DNA Degradation in TCR-Stimulated Thymocytes.

T. Nagata, H. Kishi, Q. L. Liu, T. Yoshino, T. Matsuda, Z. X. Jin, K. Murayama, K. Tsukada, and A. Muraguchi (2000)
J. Immunol. 165, 4281-4289
 |  Abstract »  |  Full Text »  |  PDF »

A Conserved Domain of the Arabidopsis GNOM Protein Mediates Subunit Interaction and Cyclophilin 5 Binding.

M. Grebe, J. Gadea, T. Steinmann, M. Kientz, J.-U. Rahfeld, K. Salchert, C. Koncz, and G. Jürgens (2000)
PLANT CELL 12, 343-356
 |  Abstract »  |  Full Text »

Biochemical and Structural Characterization of a Divergent Loop Cyclophilin from Caenorhabditis elegans.

J. Dornan, A. P. Page, P. Taylor, S.-y. Wu, A. D. Winter, H. Husi, and M. D. Walkinshaw (1999)
J. Biol. Chem. 274, 34877-34883
 |  Abstract »  |  Full Text »  |  PDF »

Calcineurin Enhances Acetylcholinesterase mRNA Stability during C2-C12 Muscle Cell Differentiation.

Z. D. Luo, Y. Wang, G. Werlen, S. Camp, K. R. Chien, and P. Taylor (1999)
Mol. Pharmacol. 56, 886-894
 |  Abstract »  |  Full Text »

Cyclophilin B Binding to Platelets Supports Calcium-Dependent Adhesion to Collagen.

F. Allain, S. Durieux, A. Denys, M. Carpentier, and G. Spik (1999)
Blood 94, 976-983
 |  Abstract »  |  Full Text »  |  PDF »

Two Distinct Regions of Cyclophilin B Are Involved in the Recognition of a Functional Receptor and of Glycosaminoglycans on T Lymphocytes.

M. Carpentier, F. Allain, B. Haendler, A. Denys, C. Mariller, M. Benaissa, and G. Spik (1999)
J. Biol. Chem. 274, 10990-10998
 |  Abstract »  |  Full Text »  |  PDF »

Cyclosporin A treatment alters characteristics of Ca2+-release channel in cardiac sarcoplasmic reticulum.

K. S. Park, T. K. Kim, and D. H. Kim (1999)
Am J Physiol Heart Circ Physiol 276, H865-H872
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-Activated Protein Kinase Activation Through Fc{epsilon} Receptor I and Stem Cell Factor Receptor Is Differentially Regulated by Phosphatidylinositol 3-Kinase and Calcineurin in Mouse Bone Marrow-Derived Mast Cells.

T. Ishizuka, K. Chayama, K. Takeda, E. Hamelmann, N. Terada, G. M. Keller, G. L. Johnson, and E. W. Gelfand (1999)
J. Immunol. 162, 2087-2094
 |  Abstract »  |  Full Text »  |  PDF »

The Wheat Peptidyl Prolyl cis-trans-Isomerase FKBP77 Is Heat Induced and Developmentally Regulated.

I. Kurek, K. Aviezer, N. Erel, E. Herman, and A. Breiman (1999)
Plant Physiology 119, 693-704
 |  Abstract »  |  Full Text »

Involvement of the Ca2+-ATPase PAT1 and the contractile vacuole in calcium regulation in Dictyostelium discoideum.

J Moniakis, M. Coukell, and A Janiec (1999)
J. Cell Sci. 112, 405-414
 |  Abstract »  |  PDF »

FK-binding Protein Is Associated with the Ryanodine Receptor of Skeletal Muscle in Vertebrate Animals.

Y. Qi, E. M. Ogunbunmi, E. A. Freund, A. P. Timerman, and S. Fleischer (1998)
J. Biol. Chem. 273, 34813-34819
 |  Abstract »  |  Full Text »  |  PDF »

Utilization of an NF-ATp Binding Promoter Element for EGR3 Expression in T Cells but Not Fibroblasts Provides a Molecular Model for the Lymphoid Cell-Specific Effect of Cyclosporin A.

H. W. Mages, R. Baag, B. Steiner, and R. A. Kroczek (1998)
Mol. Cell. Biol. 18, 7157-7165
 |  Abstract »  |  Full Text »

Human Immunodeficiency Virus Type 1 Replication Is Modulated by Host Cyclophilin A Expression Levels.

L. Yin, D. Braaten, and J. Luban (1998)
J. Virol. 72, 6430-6436
 |  Abstract »  |  Full Text »  |  PDF »

Agrobacterium VirD2 protein interacts with plant host cyclophilins.

W. Deng, L. Chen, D. W. Wood, T. Metcalfe, X. Liang, M. P. Gordon, L. Comai, and E. W. Nester (1998)
PNAS 95, 7040-7045
 |  Abstract »  |  Full Text »  |  PDF »

Matrin CYP, an SR-rich Cyclophilin That Associates with the Nuclear Matrix and Splicing Factors.

M. J. Mortillaro and R. Berezney (1998)
J. Biol. Chem. 273, 8183-8192
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical and Genetic Characterization of an FK506-Sensitive Peptidyl Prolyl cis-trans Isomerase from a Thermophilic Archaeon, Methanococcus thermolithotrophicus.

M. Furutani, T. Iida, S. Yamano, K. Kamino, and T. Maruyama (1998)
J. Bacteriol. 180, 388-394
 |  Abstract »  |  Full Text »

Discovery of Less Nephrotoxic FK506 Analogs and Determining Immunophilin Dependence of Immunosuppressant Nephrotoxicity with a Novel Single-Dose Rat Cisplatin Potentiation Assay.

K. W. Mollison, T. A. Fey, R. A. Krause, J. M. Andrews, P. T. Bretheim, J. A. Brandt, M. Kawai, R. Wagner, G. C. Hsieh, and J. R. Luly (1997)
J. Pharmacol. Exp. Ther. 283, 1509-1519
 |  Abstract »  |  Full Text »

All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in cerevisiae.

K. Dolinski, S. Muir, M. Cardenas, and J. Heitman (1997)
PNAS 94, 13093-13098
 |  Abstract »  |  Full Text »  |  PDF »

A Peptidyl-prolyl cis/trans-Isomerase (Cyclophilin G) in Regulated Secretory Granules.

Y. Takaki, T. Muta, and S. Iwanaga (1997)
J. Biol. Chem. 272, 28615-28621
 |  Abstract »  |  Full Text »  |  PDF »

Transfer of the HIV-1 cyclophilin-binding site to simian immunodeficiency virus from Macaca mulatta can confer both cyclosporin sensitivity and cyclosporin dependence.

A. A. Bukovsky, A. Weimann, M. A. Accola, and H. G. Gottlinger (1997)
PNAS 94, 10943-10948
 |  Abstract »  |  Full Text »  |  PDF »

Native Recombinant Cyclophilins A, B, and C Degrade DNA Independently of Peptidylprolyl cis-trans-Isomerase Activity. POTENTIAL ROLES OF CYCLOPHILINS IN APOPTOSIS.

J. W. Montague, F. M. Hughes Jr., and J. A. Cidlowski (1997)
J. Biol. Chem. 272, 6677-6684
 |  Abstract »  |  Full Text »  |  PDF »

A Novel FK506 Binding Protein Can Mediate the Immunosuppressive Effects of FK506 and Is Associated with the Cardiac Ryanodine Receptor.

E. Lam, M. M. Martin, A. P. Timerman, C. Sabers, S. Fleischer, T. Lukas, R. T. Abraham, S. J. O'Keefe, E. A. O'Neill, and G. J. Wiederrecht (1995)
J. Biol. Chem. 270, 26511-26522
 |  Abstract »  |  Full Text »  |  PDF »

4-(Fluoromethyl)phenyl Phosphate Acts as a Mechanism-based Inhibitor of Calcineurin.

T. L. Born, J. K. Myers, T. S. Widlanski, and F. Rusnak (1995)
J. Biol. Chem. 270, 25651-25655
 |  Abstract »  |  Full Text »  |  PDF »

Retina-specifically Expressed Novel Subtypes of Bovine Cyclophilin.

P. A. Ferreira, J. T. Hom, and W. L. Pak (1995)
J. Biol. Chem. 270, 23179-23188
 |  Abstract »  |  Full Text »  |  PDF »

Mutations That Perturb Cyclophilin A Ligand Binding Pocket Confer Cyclosporin A Resistance in Saccharomycescerevisiae.

M. E. Cardenas, E. Lim, and J. Heitman (1995)
J. Biol. Chem. 270, 20997-21002
 |  Abstract »  |  Full Text »  |  PDF »

Cyclophilin A and FKBP12 Interact with YY1 and Alter Its Transcriptional Activity.

W.-M. Yang, C. J. Inouye, and E. Seto (1995)
J. Biol. Chem. 270, 15187-15193
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of an Exchange Reaction between Soluble FKBP-12 and the FKBPbulletRyanodine Receptor Complex.

A. P. Timerman, G. Wiederrecht, A. Marcy, and S. Fleischer (1995)
J. Biol. Chem. 270, 2451-2459
 |  Abstract »  |  Full Text »  |  PDF »

A calcineurin-like gene ppb1+ in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning.

T. Yoshida, T. Toda, and M. Yanagida (1994)
J. Cell Sci. 107, 1725-1735
 |  Abstract »  |  PDF »

Toxicokinetic and Mechanistic Considerations in the Interpretation of the Rodent Bioassay.

J. S. MacDonald, G. R. Lankas, and R. E. Morrissey (1994)
Toxicol Pathol 22, 124-140
 |  Abstract »  |  PDF »

Interaction of the immunosuppressant deoxyspergualin with a member of the Hsp70 family of heat shock proteins.

S. Nadler, M. Tepper, B Schacter, and C. Mazzucco (1992)
Science 258, 484-486
 |  Abstract »  |  PDF »

A conformation of cyclosporin A in aqueous environment revealed by the X-ray structure of a cyclosporin-Fab complex.

D Altschuh, O Vix, B Rees, and J. Thierry (1992)
Science 256, 92-94
 |  Abstract »  |  PDF »

Receptor-induced conformation change of the immunosuppressant cyclosporin A.

K Wuthrich, B von Freyberg, C Weber, G Wider, R Traber, H Widmer, and W Braun (1991)
Science 254, 953-954
 |  PDF »

Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.

J Heitman, N. Movva, and M. Hall (1991)
Science 253, 905-909
 |  Abstract »  |  PDF »

Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin.

S. Michnick, M. Rosen, T. Wandless, M Karplus, and S. Schreiber (1991)
Science 252, 836-839
 |  Abstract »  |  PDF »

Chemistry and biology of the immunophilins and their immunosuppressive ligands.

S. Schreiber (1991)
Science 251, 283-287
 |  Abstract »  |  PDF »

Drug-Induced Gingival Overgrowth: Old Problem, New Problem.

T. M. Hassell and A. F. Hefti (1991)
Critical Reviews in Oral Biology & Medicine 2, 103-137
 |  Full Text »  |  PDF »

Isotope-edited NMR of cyclosporin A bound to cyclophilin: evidence for a trans 9,10 amide bond.

S. Fesik, R. Gampe Jr, T. Holzman, D. Egan, R Edalji, Luly JR, R Simmer, R Helfrich, V Kishore, and D. Rich (1990)
Science 250, 1406-1409
 |  Abstract »  |  PDF »

Probing immunosuppressant action with a nonnatural immunophilin ligand.

B. Bierer, P. Somers, T. Wandless, S. Burakoff, and S. Schreiber (1990)
Science 250, 556-559
 |  Abstract »  |  PDF »

Inhibition of FKBP rotamase activity by immunosuppressant FK506: twisted amide surrogate.

M. Rosen, R. Standaert, A Galat, M Nakatsuka, and S. Schreiber (1990)
Science 248, 863-866
 |  Abstract »  |  PDF »

Cyclosporine: An Immunosuppressant Affecting Epithelial Cell Proliferation.

J. Kanitakis and J. Thivolet (1990)
Arch Dermatol 126, 369-375
 |  Abstract »  |  PDF »

To Advertise   |   Find Products