Science 26 October 1984: Vol. 226. no. 4673, pp. 466 - 468 DOI: 10.1126/science.6093249

Prev | Table of Contents

Articles

Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations.

K. E. Coldwell, S. M. Cutts, T. J. Ognibene, P. T. Henderson, and D. R. Phillips (2008)
Nucleic Acids Res.
 |  Abstract »  |  Full Text »  |  PDF »

Synergy of a Herpes Oncolytic Virus and Paclitaxel for Anaplastic Thyroid Cancer.

S.-F. Lin, S. P. Gao, D. L. Price, S. Li, T.-C. Chou, P. Singh, Y.-Y. Huang, Y. Fong, and R. J. Wong (2008)
Clin. Cancer Res. 14, 1519-1528
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy.

Y. Nefedova, D. M. Sullivan, S. C. Bolick, W. S. Dalton, and D. I. Gabrilovich (2008)
Blood 111, 2220-2229
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Genes Required for Protection from Doxorubicin by a Genome-Wide Screen in Saccharomyces cerevisiae.

L. Xia, L. Jaafar, A. Cashikar, and H. Flores-Rozas (2007)
Cancer Res. 67, 11411-11418
 |  Abstract »  |  Full Text »  |  PDF »

Topoisomerase II{beta} Mediated DNA Double-Strand Breaks: Implications in Doxorubicin Cardiotoxicity and Prevention by Dexrazoxane.

Y. L. Lyu, J. E. Kerrigan, C.-P. Lin, A. M. Azarova, Y.-C. Tsai, Y. Ban, and L. F. Liu (2007)
Cancer Res. 67, 8839-8846
 |  Abstract »  |  Full Text »  |  PDF »

Doxorubicin Enhances the Expression of Transgene Under Control of the CMV Promoter in Anaplastic Thyroid Carcinoma Cells.

K. I. Kim, J. H. Kang, J.-K. Chung, Y. J. Lee, J. M. Jeong, D. S. Lee, and M. C. Lee (2007)
J. Nucl. Med. 48, 1553-1561
 |  Abstract »  |  Full Text »  |  PDF »

From the Cover: Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

A. M. Azarova, Y. L. Lyu, C.-P. Lin, Y.-C. Tsai, J. Y.-N. Lau, J. C. Wang, and L. F. Liu (2007)
PNAS 104, 11014-11019
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacodiagnostics and Targeted Therapies--A Rational Approach for Individualizing Medical Anticancer Therapy in Breast Cancer.

J. T. Jorgensen, K. V. Nielsen, and B. Ejlertsen (2007)
Oncologist 12, 397-405
 |  Abstract »  |  Full Text »  |  PDF »

Disruption of COX-2 modulates gene expression and the cardiac injury response to doxorubicin.

T. G. Neilan, G. A. Doherty, G. Chen, C. Deflandre, H. McAllister, R. K. Butler, S. E. McClelland, E. Kay, L. R. Ballou, and D. J. Fitzgerald (2006)
Am J Physiol Heart Circ Physiol 291, H532-H536
 |  Abstract »  |  Full Text »  |  PDF »

Iloprost attenuates doxorubicin-induced cardiac injury in a murine model without compromising tumour suppression.

T. G. Neilan, D. S. Jassal, M. F. Scully, G. Chen, C. Deflandre, H. McAllister, E. Kay, S. C. Austin, E. F. Halpern, J. H. Harmey, et al. (2006)
Eur. Heart J. 27, 1251-1256
 |  Abstract »  |  Full Text »  |  PDF »

Doxorubicin-DNA Adducts Induce a Non-Topoisomerase II-Mediated Form of Cell Death..

L. P. Swift, A. Rephaeli, A. Nudelman, D. R. Phillips, and S. M. Cutts (2006)
Cancer Res. 66, 4863-4871
 |  Abstract »  |  Full Text »  |  PDF »

Cell Adhesion to Fibronectin (CAM-DR) Influences Acquired Mitoxantrone Resistance in U937 Cells.

L. A. Hazlehurst, R. F. Argilagos, M. Emmons, D. Boulware, C. A. Beam, D. M. Sullivan, and W. S. Dalton (2006)
Cancer Res. 66, 2338-2345
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of Chromatin-associated Plk1 and Mcm7.

L. Tsvetkov and D. F. Stern (2005)
J. Biol. Chem. 280, 11943-11947
 |  Abstract »  |  Full Text »  |  PDF »

The Antitumor Triazoloacridone C-1305 Is a Topoisomerase II Poison with Unusual Properties.

K. Lemke, V. Poindessous, A. Skladanowski, and A. K. Larsen (2004)
Mol. Pharmacol. 66, 1035-1042
 |  Abstract »  |  Full Text »  |  PDF »

Retinoic Acid Increases the Expression of p53 and Proapoptotic Caspases and Sensitizes Keratinocytes to Apoptosis: A Possible Explanation for Tumor Preventive Action of Retinoids.

P. Mrass, M. Rendl, M. Mildner, F. Gruber, B. Lengauer, C. Ballaun, L. Eckhart, and E. Tschachler (2004)
Cancer Res. 64, 6542-6548
 |  Abstract »  |  Full Text »  |  PDF »

Effects of vitamin A on doxorubicin-induced chromosomal aberrations in bone marrow cells of rats.

M. D. Gulkac, G. Akpinar, H. Ustun, and A. Ozon Kanli (2004)
Mutagenesis 19, 231-236
 |  Abstract »  |  Full Text »  |  PDF »

Hydropathic analysis of the free energy differences in anthracycline antibiotic binding to DNA.

D. J. Cashman, J. N. Scarsdale, and G. E. Kellogg (2003)
Nucleic Acids Res. 31, 4410-4416
 |  Abstract »  |  Full Text »  |  PDF »

Investigations into the concept of a threshold for topoisomerase inhibitor-induced clastogenicity.

A. Lynch, J. Harvey, M. Aylott, E. Nicholas, M. Burman, A. Siddiqui, S. Walker, and R. Rees (2003)
Mutagenesis 18, 345-353
 |  Abstract »  |  Full Text »  |  PDF »

The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexes.

C. Temperini, L. Messori, P. Orioli, C. D. Bugno, F. Animati, and G. Ughetto (2003)
Nucleic Acids Res. 31, 1464-1469
 |  Abstract »  |  Full Text »  |  PDF »

Therapy-Induced Leukemias and Myelodysplastic Syndromes After Breast Cancer Treatment: An Underemphasized Clinical Problem.

C. B. Weldon, B. M. Jaffe, and M. J. Kahn (2002)
Ann. Surg. Oncol. 9, 738-744
 |  Full Text »  |  PDF »

Molecular Characterization of Recombinant Pneumocystis carinii Topoisomerase I: Differential Interactions with Human Topoisomerase I Poisons and Pentamidine.

R. T. Van Dross and M. M. Sanders (2002)
Antimicrob. Agents Chemother. 46, 2145-2154
 |  Abstract »  |  Full Text »  |  PDF »

p53 Mediates DNA Damaging Drug-induced Apoptosis through a Caspase-9-dependent Pathway in SH-SY5Y Neuroblastoma Cells.

H. Cui, A. Schroering, and H.-F. Ding (2002)
Mol. Cancer Ther. 1, 679-686
 |  Abstract »  |  Full Text »  |  PDF »

Flow cytometric analysis of the cell cycle phase specificity of DNA damage induced by radiation, hydrogen peroxide and doxorubicin.

A. J. Potter, K. A. Gollahon, B. J.A. Palanca, M. J. Harbert, Y. M. Choi, A. H. Moskovitz, J. D. Potter, and P. S. Rabinovitch (2002)
Carcinogenesis 23, 389-401
 |  Abstract »  |  Full Text »  |  PDF »

Reduction in drug-induced DNA double-strand breaks associated with {beta}1 integrin-mediated adhesion correlates with drug resistance in U937 cells.

L. A. Hazlehurst, N. Valkov, L. Wisner, J. A. Storey, D. Boulware, D. M. Sullivan, and W. S. Dalton (2001)
Blood 98, 1897-1903
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Signal Transducer and Activator of Transcription 3 Protects Cardiomyocytes from Hypoxia/Reoxygenation-Induced Oxidative Stress Through the Upregulation of Manganese Superoxide Dismutase.

S. Negoro, K. Kunisada, Y. Fujio, M. Funamoto, M. I. Darville, D. L. Eizirik, T. Osugi, M. Izumi, Y. Oshima, Y. Nakaoka, et al. (2001)
Circulation 104, 979-981
 |  Abstract »  |  Full Text »  |  PDF »

Topoisomerase II{{alpha}} and II{beta} expression in childhood acute lymphoblastic leukaemia: relation to prognostic factors and clinical outcome.

A J Lodge, A G Hall, M M Reid, G G McIntosh, M Steward, J J Anderson, C H W Horne, and B Angus (2001)
J. Clin. Pathol. 54, 31-36
 |  Abstract »  |  Full Text »  |  PDF »

Roles of Nuclear Factor-kappa B, p53, and p21/WAF1 in Daunomycin-Induced Cell Cycle Arrest and Apoptosis.

A.-C. Hellin, M. Bentires-Alj, M. Verlaet, V. Benoit, J. Gielen, V. Bours, and M.-P. Merville (2000)
J. Pharmacol. Exp. Ther. 295, 870-878
 |  Abstract »  |  Full Text »

Anticancer Derivative of Butyric Acid (Pivalyloxymethyl Butyrate) Specifically Potentiates the Cytotoxicity of Doxorubicin and Daunorubicin through the Suppression of Microsomal Glycosidic Activity.

N. Niitsu, T. Kasukabe, A. Yokoyama, J. Okabe-Kado, Y. Yamamoto-Yamaguchi, M. Umeda, and Y. Honma (2000)
Mol. Pharmacol. 58, 27-36
 |  Abstract »  |  Full Text »

Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathy.

K. Kunisada, S. Negoro, E. Tone, M. Funamoto, T. Osugi, S. Yamada, M. Okabe, T. Kishimoto, and K. Yamauchi-Takihara (2000)
PNAS 97, 315-319
 |  Abstract »  |  Full Text »  |  PDF »

Protein tyrosine kinase Lyn mediates apoptosis induced by topoisomerase II inhibitors in DT40 cells.

A. Maruo, I. Oishi, K. Sada, M. Nomi, T. Kurosaki, Y. Minami, and H. Yamamura (1999)
Int. Immunol. 11, 1371-1380
 |  Abstract »  |  Full Text »  |  PDF »

Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress.

T.-K. Li, A. Y. Chen, C. Yu, Y. Mao, H. Wang, and L. F. Liu (1999)
Genes & Dev. 13, 1553-1560
 |  Abstract »  |  Full Text »

Double-Stranded-RNA-Activated Protein Kinase PKR Enhances Transcriptional Activation by Tumor Suppressor p53.

A. R. Cuddihy, S. Li, N. W. N. Tam, A. H.-T. Wong, Y. Taya, N. Abraham, J. C. Bell, and A. E. Koromilas (1999)
Mol. Cell. Biol. 19, 2475-2484
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Cellular ATP Depletion on Topoisomerase II Poisons. Abrogation of Cleavable-Complex Formation by Etoposide But Not by Amsacrine.

M. Sorensen, M. Sehested, and P. B. Jensen (1999)
Mol. Pharmacol. 55, 424-431
 |  Abstract »  |  Full Text »

Antineoplastic Efficacy of Doxorubicin Enzymatically Assembled on Galactose Residues of a Monoclonal Antibody Specific for the Carcinoembryonic Antigen.

A. C. Stan, D. L. Radu, S. Casares, C. A. Bona, and T.-D. Brumeanu (1999)
Cancer Res. 59, 115-121
 |  Abstract »  |  Full Text »  |  PDF »

Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites.

Y. Kwok, Q. Zeng, and L. H. Hurley (1998)
PNAS 95, 13531-13536
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Yeast DNA Topoisomerase II Mutants Resistant to the Antitumor Drug Doxorubicin: Implications for the Mechanisms of Doxorubicin Action and Cytotoxicity.

S. Patel, A. U. Sprung, B. A. Keller, V. J. Heaton, and L. M. Fisher (1997)
Mol. Pharmacol. 52, 658-666
 |  Abstract »  |  Full Text »

Topoisomerase IV, not gyrase, decatenates products of site-specific recombination in Escherichia coli.

E. L. Zechiedrich, A. B. Khodursky, and N. R. Cozzarelli (1997)
Genes & Dev. 11, 2580-2592
 |  Abstract »  |  Full Text »  |  PDF »

Activation of NF-kappa B by Antineoplastic Agents. ROLE OF PROTEIN KINASE C.

K. C. Das and C. W. White (1997)
J. Biol. Chem. 272, 14914-14920
 |  Abstract »  |  Full Text »  |  PDF »

Relationship between Lethal Effects and Topoisomerase II-Mediated Double-Stranded DNA Breaks Produced by Anthracyclines with Different Sequence Specificity.

M. Binaschi, G. Capranico, L. Dal Bo, and F. Zunino (1997)
Mol. Pharmacol. 51, 1053-1059
 |  Abstract »  |  Full Text »

Vesicular Anthracycline Accumulation in Doxorubicin-Selected U-937 Cells: Participation of Lysosomes.

S. J. Hurwitz, M. Terashima, N. Mizunuma, and C. A. Slapak (1997)
Blood 89, 3745-3754
 |  Abstract »  |  Full Text »  |  PDF »

Correlation between the Formation of Cleavable Complex with Topoisomerase I and Growth-Inhibitory Activity for Saintopin-Type Antibiotics.

N. Fujii, Y. Yamashita, T. Mizukami, and H. Nakano (1997)
Mol. Pharmacol. 51, 269-276
 |  Abstract »  |  Full Text »  |  PDF »

DNA Strand Cleavage Is Required for Replication Fork Arrest by a Frozen Topoisomerase-Quinolone-DNA Ternary Complex.

H. Hiasa, D. O. Yousef, and K. J. Marians (1996)
J. Biol. Chem. 271, 26424-26429
 |  Abstract »  |  Full Text »  |  PDF »

Isobolographic Assessment of the Interaction Between Adriamycin and Photodynamic Therapy With Meso-Chlorin E6 Monoethylene Diamine in Human Epithelial Overian Carcinoma (OVCAR-3) In Vitro.

M. C. Peterson, J. M. Lu, Z.-w. Gu, J.-G. Shiah, K. Lythgoe, A. C. Peterson, R. C. Straight, and J. Kopee (1995)
Reproductive Sciences 2, 772-777
 |  Abstract »  |  PDF »

Determination of 5` and 3` DNA Triplex Interference Boundaries Reveals the Core DNA Binding Sequence for Topoisomerase II.

J. R. Spitzner, I. K. Chung, and M. T. Muller (1995)
J. Biol. Chem. 270, 5932-5943
 |  Abstract »  |  Full Text »  |  PDF »

Human Mismatch Repair and G{middle dot}T Mismatch Binding by hMutSalpha in Vitro Is Inhibited by Adriamycin, Actinomycin D, and Nogalamycin.

E. D. Larson and J. T. Drummond (2001)
J. Biol. Chem. 276, 9775-9783
 |  Abstract »  |  Full Text »  |  PDF »

ATP-bound Topoisomerase II as a Target for Antitumor Drugs.

H. Wang, Y. Mao, N. Zhou, T. Hu, T.-S. Hsieh, and L. F. Liu (2001)
J. Biol. Chem. 276, 15990-15995
 |  Abstract »  |  Full Text »  |  PDF »

Nucleolytic Cleavage of the Mixed Lineage Leukemia Breakpoint Cluster Region during Apoptosis.

S.-P. Sim and L. F. Liu (2001)
J. Biol. Chem. 276, 31590-31595
 |  Abstract »  |  Full Text »  |  PDF »

S Phase and G2 Arrests Induced by Topoisomerase I Poisons Are Dependent on ATR Kinase Function.

W. A. Cliby, K. A. Lewis, K. K. Lilly, and S. H. Kaufmann (2002)
J. Biol. Chem. 277, 1599-1606
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products