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Science 26 October 1984:
Vol. 226. no. 4673, pp. 462 - 464
DOI: 10.1126/science.6541807
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Articles

Science, Vol 226, Issue 4673, 462-464
Copyright © 1984 by American Association for the Advancement of Science

articles

Separation of morphine analgesia from physical dependence

GS Ling, JM MacLeod, S Lee, SH Lockhart, and GW Pasternak

Intravenous infusion of morphine sulfate in rats for 24 hours produced marked opioid dependence, manifested by a series of well-documented signs appearing after injection of the opiate antagonist naloxone. Treatment of rats with naloxonazine significantly reduced the analgesia associated with the morphine infusions for more than 24 hours. Furthermore, 14 of 16 withdrawal signs observed in naloxonazine-treated rats were virtually identical to those in rats that received morphine alone. These results raise the possibility that different receptor mechanisms mediate morphine analgesia and many of the withdrawal signs associated with morphine dependence.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Separation of Binding Affinity and Intrinsic Activity of the Potent {micro}-Opioid 14-Methoxymetopon.
L. Mahurter, C. Garceau, J. Marino, H. Schmidhammer, G. Toth, and G. W. Pasternak (2006)
J. Pharmacol. Exp. Ther. 319, 247-253
   Abstract »    Full Text »    PDF »
Identification of Four Novel Exon 5 Splice Variants of the Mouse {micro}-Opioid Receptor Gene: Functional Consequences of C-Terminal Splicing.
Y.-X. Pan, J. Xu, E. Bolan, H. S. Moskowitz, M. Xu, and G. W. Pasternak (2005)
Mol. Pharmacol. 68, 866-875
   Abstract »    Full Text »    PDF »
Book Review: The Pharmacology of Mu Analgesics: From Patients to Genes.
G. W. Pasternak (2001)
Neuroscientist 7, 220-231
   Abstract »    PDF »
Antisense Oligodeoxynucleotides to Opioid Mu and Delta Receptors Reduced Morphine Dependence in Mice: Role of Delta-2 Opioid Receptors.
P. Sánchez-Blázquez, A. García-España, and J. Garzón (1997)
J. Pharmacol. Exp. Ther. 280, 1423-1431
   Abstract »    Full Text »
Multiple Morphine and Enkephalin Receptors and the Relief of Pain.
G. W. Pasternak (1988)
JAMA 259, 1362-1367
   Abstract »    PDF »


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