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Science 19 October 1984:
Vol. 226. no. 4672, pp. 350 - 352
DOI: 10.1126/science.6091272
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Articles

Science, Vol 226, Issue 4672, 350-352
Copyright © 1984 by American Association for the Advancement of Science

articles

Frequency-dependent noradrenergic modulation of long-term potentiation in the hippocampus

WF Hopkins and D Johnston

Norepinephrine, briefly superfused during high-frequency stimulation of the mossy fibers in the rat hippocampal slice in vitro, produced a reversible increase in the magnitude, duration, and probability of induction of long-term synaptic potentiation in the CA3 subfield. Similar results were obtained with isoproterenol, whereas propranolol or timolol reversibly blocked long-term potentiation. Norepinephrine had little apparent effect on responses obtained during low-frequency stimulation of the mossy fibers. These data suggest that norepinephrine can mediate long-lasting, frequency-dependent modulation of synaptic transmission in the mammalian brain. Furthermore, the results suggest a plausible mechanism for some of the known associative interactions between synaptic inputs to hippocampal neurons.


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