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Science 19 October 1984:
Vol. 226. no. 4672, pp. 348 - 349
DOI: 10.1126/science.6435246
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Articles

Science, Vol 226, Issue 4672, 348-349
Copyright © 1984 by American Association for the Advancement of Science

articles

Chromosomal location of human T-cell receptor gene Ti beta

PE Barker, FH Ruddle, HD Royer, O Acuto, and EL Reinherz

A complementary DNA probe corresponding to the beta-chain gene of Ti, the human T lymphocyte receptor, has been molecularly cloned. The chromosomal origin of the Ti beta gene was determined with the complementary DNA by screening a series of 12 cell hybrid (mouse X human) DNA's containing overlapping subsets of human chromosomes. DNA hybridization (Southern) experiments showed that the human Ti beta gene resides on chromosome 7 and is thus not linked to the immunoglobulin loci or to the major histocompatibility locus in humans.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Analysis of T-cell receptor gene rearrangement and expression in human natural killer clones.
J Ritz, T. Campen, R. Schmidt, H. Royer, T Hercend, R. Hussey, and E. Reinherz (1985)
Science 228, 1540-1543
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Localization of the gene encoding the human interleukin-2 receptor on chromosome 10.
W. Leonard, T. Donlon, R. Lebo, and W. Greene (1985)
Science 228, 1547-1549
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Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells.
M Isobe, J Erikson, B. Emanuel, P. Nowell, and C. Croce (1985)
Science 228, 580-582
   Abstract »    PDF »
Genes for beta chain of human T-cell antigen receptor map to regions of chromosomal rearrangement in T cells.
C. Morton, A. Duby, R. Eddy, T. Shows, and J. Seidman (1985)
Science 228, 582-585
   Abstract »    PDF »


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