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Science 19 October 1984:
Vol. 226. no. 4672, pp. 254 - 261
DOI: 10.1126/science.226.4672.254
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Articles

Trends in Analytical Scale Separations

James W. Jorgenson 1

1 Assistant professor in the Department of Chemistry, University of North Carolina, Chapel Hill 27514.

Although gas chromatography has been called a mature technology, advances are still being made in the development of faster columns as well as detectors which yield more information on solutes. In liquid chromatography short columns packed with 3-micrometer particles are already popular for fast analyses, while long narrow-bore columns are being developed for high-resolution separations. An increasing range of detection modes is enhancing the problem-solving capabilities of liquid chromatography. Electrophoresis continues to be of central importance to molecular biology. Computer-aided analysis and display of electropherogram patterns is helping researchers to better comprehend the wealth of data from two-dimensional electrophoresis. A new mode of two-dimensional electrophoresis is permitting separation of whole chromosomes containing as many as 3 million base pairs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Recent Developments in Analytical Chromatography.
M. V. Novotny and M. V. NOVOTNY (1989)
Science 246, 51-57
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