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Science 12 October 1984:
Vol. 226. no. 4671, pp. 187 - 190
DOI: 10.1126/science.6484570
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Articles

Science, Vol 226, Issue 4671, 187-190
Copyright © 1984 by American Association for the Advancement of Science

articles

Regulation of a hybrid gene by glucose and temperature in hamster fibroblasts

JW Attenello and AS Lee

A novel eukaryotic hybrid gene has been constructed from the 5' sequence of a rat gene and the bacterial neomycin-resistance gene. After transfection into hamster fibroblasts, the neo transcripts can be induced to high levels by the absence of glucose. Furthermore, this hybrid gene can be regulated by temperature when it is introduced into a temperature-sensitive mutant cell line.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Use of the Glucose Starvation-inducible Glucose-regulated Protein 78 Promoter in Suicide Gene Therapy of Murine Fibrosarcoma.
G. Gazit, G. Hung, X. Chen, W. F. Anderson, and A. S. Lee (1999)
Cancer Res. 59, 3100-3106
   Abstract »    Full Text »    PDF »
Isolation of a mammalian sequence capable of conferring cell cycle regulation to a heterologous gene.
A Artishevsky, A Grafsky, and A. Lee (1985)
Science 230, 1061-1063
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)