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Science 12 October 1984:
Vol. 226. no. 4671, pp. 177 - 179
DOI: 10.1126/science.6091270
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Articles

Science, Vol 226, Issue 4671, 177-179
Copyright © 1984 by American Association for the Advancement of Science

articles

Expression of the 3' terminal region of human T-cell leukemia viruses

W Wachsman, K Shimotohno, SC Clark, DW Golde, and IS Chen

Human T-cell leukemia viruses (HTLV) are closely associated with some human T-cell leukemias and lymphomas. A unique 3' region of the HTLV genome is believed to be involved in HTLV-induced cellular transformation, although the function of this region has yet to be determined. A subgenomic messenger RNA transcribed from this region of HTLV has now been characterized. These results provide direct evidence for the expression of a novel gene in HTLV.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhibition of the Tax-Dependent Human T-Lymphotropic Virus Type I Replication in Persistently Infected Cells by the Fluoroquinolone Derivative K-37.
X. Wang, H. Miyake, M. Okamoto, M. Saito, J.-I. Fujisawa, Y. Tanaka, S. Izumo, and M. Baba (2002)
Mol. Pharmacol. 61, 1359-1365
   Abstract »    Full Text »    PDF »
Cloning of Novel Isoforms of the Human Gli2 Oncogene and Their Activities To Enhance Tax-Dependent Transcription of the Human T-Cell Leukemia Virus Type 1 Genome.
A. Tanimura, S. Dan, and M. Yoshida (1998)
J. Virol. 72, 3958-3964
   Abstract »    Full Text »    PDF »
Specific interaction of HTLV tax protein and a human type IV neuronal intermediate filament protein.
T. R. Reddy, X. Li, Y. Jones, M. H. Ellisman, G. Y. Ching, R. K. H. Liem, and F. Wong-Staal (1998)
PNAS 95, 702-707
   Abstract »    Full Text »    PDF »
The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice.
M Nerenberg, S. Hinrichs, R. Reynolds, G Khoury, and G Jay (1987)
Science 237, 1324-1329
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The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats.
B. Felber, H Paskalis, C Kleinman-Ewing, F Wong-Staal, and G. Pavlakis (1985)
Science 229, 675-679
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The x gene is essential for HTLV replication.
I. Chen, D. Slamon, J. Rosenblatt, N. Shah, S. Quan, and W Wachsman (1985)
Science 229, 54-58
   Abstract »    PDF »
Expression of the pX gene of HTLV-I: general splicing mechanism in the HTLV family.
M Seiki, A Hikikoshi, T Taniguchi, and M Yoshida (1985)
Science 228, 1532-1534
   Abstract »    PDF »
HTLV x-gene product: requirement for the env methionine initiation codon.
W Wachsman, D. Golde, P. Temple, E. Orr, S. Clark, and I. Chen (1985)
Science 228, 1534-1537
   Abstract »    PDF »
Studies of the putative transforming protein of the type I human T-cell leukemia virus.
D. Slamon, M. Press, L. Souza, D. Murdock, M. Cline, D. Golde, J. Gasson, and I. Chen (1985)
Science 228, 1427-1430
   Abstract »    PDF »
A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus.
J Sodroski, C Rosen, W. Goh, and W Haseltine (1985)
Science 228, 1430-1434
   Abstract »    PDF »
Subcellular localization of the product of the long open reading frame of human T-cell leukemia virus type I.
W. Goh, J Sodroski, C Rosen, M Essex, and W. Haseltine (1985)
Science 227, 1227-1228
   Abstract »    PDF »


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