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Science 12 October 1984:
Vol. 226. no. 4671, pp. 172 - 174
DOI: 10.1126/science.6091268
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Articles

Science, Vol 226, Issue 4671, 172-174
Copyright © 1984 by American Association for the Advancement of Science

articles

Suramin protection of T cells in vitro against infectivity and cytopathic effect of HTLV-III

H Mitsuya, M Popovic, R Yarchoan, S Matsushita, RC Gallo, and S Broder

A recently discovered member of the human T-cell leukemia virus (HTLV) family of retroviruses has been etiologically linked to the acquired immune deficiency syndrome (AIDS). This virus, which has been designated HTLV-III, is tropic for OKT4-bearing (helper-inducer) T cells. Moreover, the virus is cytopathic for these cells. Suramin is a drug used in the therapy of Rhodesian trypanosomiasis and onchocerciasis, and it is known to inhibit the reverse transcriptase of a number of retroviruses. Suramin has now been found to block in vitro the infectivity and cytopathic effect of HTLV-III at doses that are clinically attainable in human beings.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Inhibition of Neutrophil Serine Proteinases by Suramin.
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J. Biol. Chem. 272, 9950-9955
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Suramin-Induced Skin Reactions.
B. P. O'Donnell, N. A. Dawson, R. B. Weiss, C. E. Myers, and W. D. James (1992)
Arch Dermatol 128, 75-79
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Antiretroviral Therapy in AIDS.
S. Broder, H. Mitsuya, R. Yarchoan, and G. N. Pavlakis (1990)
Ann Intern Med 113, 604-618
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Combined Zidovudine and Interferon-{alpha} Therapy in Patients with Kaposi Sarcoma and the Acquired Immunodeficiency Syndrome (AIDS).
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Ann Intern Med 111, 280-287
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Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells.
H Mitsuya, D. Looney, S Kuno, R Ueno, F Wong-Staal, and S Broder (1988)
Science 240, 646-649
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Persistence of Human Immunodeficiency Virus Antigenemia in Patients With the Acquired Immunodeficiency Syndrome Treated With a Reverse Transcriptase Inhibitor, Suramin: Ten-Patient Case-Control Study.
J. K. M. E. Schattenkerk, S. A. Danner, J. M. A. Lange, D. A. Paul, C. J. van Boxtel, F. Miedema, P. Th. A. Schellekens, and J. Goudsmit (1988)
Arch Intern Med 148, 209-211
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Suramin Therapy in AIDS and Related Disorders: Report of the US Suramin Working Group.
B. D. Cheson, A. M. Levine, D. Mildvan, L. D. Kaplan, P. Wolfe, A. Rios, J. E. Groopman, P. Gill, P. A. Volberding, B. J. Poiesz, et al. (1987)
JAMA 258, 1347-1351
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Suramin Antiviral Therapy in the Acquired Immunodeficiency Syndrome: Clinical, Immunologic, and Virologic Results.
A. M. LEVINE, P. S. GILL, J. COHEN, J. G. HAWKINS, S. C. FORMENTI, S. AGUILAR, P. R. MEYER, M. KRAILO, J. PARKER, and S. RASHEED (1986)
Ann Intern Med 105, 32-37
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Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV.
F di Marzo Veronese, T. Copeland, A. DeVico, R Rahman, S Oroszlan, R. Gallo, and M. Sarngadharan (1986)
Science 231, 1289-1291
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Suramin and Function of the Adrenal Cortex.
C. A. STEIN, W. SAVILLE, R. YARCHOAN, S. BRODER, and E. P. GELMANN (1986)
Ann Intern Med 104, 286-287
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Prospects of Therapy for Infections with Human T-Lymphotropic Virus Type III.
M. S. HIRSCH and J. C. KAPLAN (1985)
Ann Intern Med 103, 750-755
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The Acquired Immunodeficiency Syndrome: An Update.
A. S. FAUCI, H. MASUR, E. P. GELMANN, P. D. MARKHAM, B. H. HAHN, and H. C. LANE (1985)
Ann Intern Med 102, 800-813
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The AIDS Connection.
G. K. (1984)
Science 226, 958
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