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Science 5 October 1984:
Vol. 226. no. 4670, pp. 72 - 74
DOI: 10.1126/science.6433485
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Articles

Science, Vol 226, Issue 4670, 72-74
Copyright © 1984 by American Association for the Advancement of Science

articles

Interruption of the mammillothalamic tract prevents seizures in guinea pigs

MA Mirski and JA Ferrendelli

Interruption of the connection between the mammillary bodies and the anterior nucleus of the thalamus in guinea pigs, by discrete bilateral electrolytic lesions of the mammillothalamic tract, resulted in essentially complete protection from the behavioral and electroencephalographic convulsant action and lethal effect of pentylenetetrazol. This result demonstrates that the mammillary bodies and their rostral efferent connections are important for the propagation and perhaps initiation of generalized seizures.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
MR Imaging and Spectroscopic Study of Epileptogenic Hypothalamic Hamartomas: Analysis of 72 Cases.
J. L. Freeman, L. T. Coleman, R. M. Wellard, M. J. Kean, J. V. Rosenfeld, G. D. Jackson, S. F. Berkovic, and A. S. Harvey (2004)
AJNR Am. J. Neuroradiol. 25, 450-462
   Abstract »    Full Text »    PDF »
Cellular mechanisms of epilepsy: a status report.
M. Dichter and G. Ayala (1987)
Science 237, 157-164
   Abstract »    PDF »


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